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Modified microvessel density based on perfusion distance: a preferable NSCLC prognostic factor
BACKGROUND: Despite the vital role of blood perfusion in tumor progression, the prognostic value of typical blood perfusion markers, such as microvessel density (MVD) or microvessel area (MVA), in patients with non-small cell lung cancer (NSCLC) is still unclear. This study established a modified MV...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848420/ https://www.ncbi.nlm.nih.gov/pubmed/35282046 http://dx.doi.org/10.21037/atm-21-6566 |
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author | Tong, Yinghui Yang, Dihong Mi, Xiufang Song, Yu Xin, Wenxiu Zhong, Like Shi, Zheng Xu, Gaoqi Ding, Haiying Fang, Luo |
author_facet | Tong, Yinghui Yang, Dihong Mi, Xiufang Song, Yu Xin, Wenxiu Zhong, Like Shi, Zheng Xu, Gaoqi Ding, Haiying Fang, Luo |
author_sort | Tong, Yinghui |
collection | PubMed |
description | BACKGROUND: Despite the vital role of blood perfusion in tumor progression, the prognostic value of typical blood perfusion markers, such as microvessel density (MVD) or microvessel area (MVA), in patients with non-small cell lung cancer (NSCLC) is still unclear. This study established a modified MVD (mMVD) measurement based on perfusion distance and determined its prognostic value in patients with NSCLC. METHODS: A total of 100 patients with NSCLC were enrolled in this retrospective study. The intratumor microvessels of NSCLC patients were visualized using immunohistochemical staining for CD31. The blood perfusion distance was evaluated as the distance from each vessel to its nearest cancer cell (D(mvcc)), and the cutoff value for prognosis was determined. Apart from the total MVD (tMVD), microvessels near cancer cells within the cutoff-D(mvcc) were counted as mMVD. Predictive values for mortality and recurrence were evaluated and compared. RESULTS: The D(mvcc) ranged from 1.6 to 269.8 µm (median, 13.1 µm). The mMVD (range: 2–70; median 23) was counted from tMVD according to the cutoff-D(mvcc) (~20 µm). Compared with tMVD, a larger fraction of mMVD (80% vs. 2.9%) played a significant role in overall survival, with an improved area under the receiver operating characteristic (ROC) curve (AUC) (0.74 vs. 0.56). A high mMVD was an independent positive indicator of overall survival (OS) and progression-free survival (PFS). In contrast, tMVD was only related to PFS at the optimal cutoff. CONCLUSIONS: Perfusion-distance-based mMVD is a promising prognostic factor for NSCLC patients with superior sensitivity, specificity, and clinical applicability compared to tMVD. This study provides novel insights into the prognostic role of tumor vessel perfusion in patients with NSCLC. |
format | Online Article Text |
id | pubmed-8848420 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-88484202022-03-10 Modified microvessel density based on perfusion distance: a preferable NSCLC prognostic factor Tong, Yinghui Yang, Dihong Mi, Xiufang Song, Yu Xin, Wenxiu Zhong, Like Shi, Zheng Xu, Gaoqi Ding, Haiying Fang, Luo Ann Transl Med Original Article BACKGROUND: Despite the vital role of blood perfusion in tumor progression, the prognostic value of typical blood perfusion markers, such as microvessel density (MVD) or microvessel area (MVA), in patients with non-small cell lung cancer (NSCLC) is still unclear. This study established a modified MVD (mMVD) measurement based on perfusion distance and determined its prognostic value in patients with NSCLC. METHODS: A total of 100 patients with NSCLC were enrolled in this retrospective study. The intratumor microvessels of NSCLC patients were visualized using immunohistochemical staining for CD31. The blood perfusion distance was evaluated as the distance from each vessel to its nearest cancer cell (D(mvcc)), and the cutoff value for prognosis was determined. Apart from the total MVD (tMVD), microvessels near cancer cells within the cutoff-D(mvcc) were counted as mMVD. Predictive values for mortality and recurrence were evaluated and compared. RESULTS: The D(mvcc) ranged from 1.6 to 269.8 µm (median, 13.1 µm). The mMVD (range: 2–70; median 23) was counted from tMVD according to the cutoff-D(mvcc) (~20 µm). Compared with tMVD, a larger fraction of mMVD (80% vs. 2.9%) played a significant role in overall survival, with an improved area under the receiver operating characteristic (ROC) curve (AUC) (0.74 vs. 0.56). A high mMVD was an independent positive indicator of overall survival (OS) and progression-free survival (PFS). In contrast, tMVD was only related to PFS at the optimal cutoff. CONCLUSIONS: Perfusion-distance-based mMVD is a promising prognostic factor for NSCLC patients with superior sensitivity, specificity, and clinical applicability compared to tMVD. This study provides novel insights into the prognostic role of tumor vessel perfusion in patients with NSCLC. AME Publishing Company 2022-01 /pmc/articles/PMC8848420/ /pubmed/35282046 http://dx.doi.org/10.21037/atm-21-6566 Text en 2022 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Original Article Tong, Yinghui Yang, Dihong Mi, Xiufang Song, Yu Xin, Wenxiu Zhong, Like Shi, Zheng Xu, Gaoqi Ding, Haiying Fang, Luo Modified microvessel density based on perfusion distance: a preferable NSCLC prognostic factor |
title | Modified microvessel density based on perfusion distance: a preferable NSCLC prognostic factor |
title_full | Modified microvessel density based on perfusion distance: a preferable NSCLC prognostic factor |
title_fullStr | Modified microvessel density based on perfusion distance: a preferable NSCLC prognostic factor |
title_full_unstemmed | Modified microvessel density based on perfusion distance: a preferable NSCLC prognostic factor |
title_short | Modified microvessel density based on perfusion distance: a preferable NSCLC prognostic factor |
title_sort | modified microvessel density based on perfusion distance: a preferable nsclc prognostic factor |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848420/ https://www.ncbi.nlm.nih.gov/pubmed/35282046 http://dx.doi.org/10.21037/atm-21-6566 |
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