Cargando…

A transcriptomic analysis based on aberrant methylation levels revealed potential novel therapeutic targets for nasopharyngeal carcinoma

BACKGROUND: This study aimed to identify potential novel therapeutic targets for nasopharyngeal carcinoma (NPC) by identifying aberrantly methylated-differentially expressed genes (DEGs) and pathways based on a comprehensive bioinformatics analysis. METHODS: Eight gene expression data sets and 2 met...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lyu, Mo, Yi, Xinzhu, Huang, Zhiwei, Chen, Yirong, Ai, Zhu, Liang, Yuying, Feng, Qili, Xiang, Zhiming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848444/ https://www.ncbi.nlm.nih.gov/pubmed/35282089 http://dx.doi.org/10.21037/atm-21-6628

Ejemplares similares

Pre-operative Prediction of Ki-67 Expression in Various Histological Subtypes of Lung Adenocarcinoma Based on CT Radiomic Features
por: Huang, Zhiwei, et al.
Publicado: (2021)

Value of IVIM in Differential Diagnoses between Benign and Malignant Solitary Lung Nodules and Masses: A Meta-analysis
por: Chen, Yirong, et al.
Publicado: (2022)

Comparative methylome analysis in solid tumors reveals aberrant methylation at chromosome 6p in nasopharyngeal carcinoma
por: Dai, Wei, et al.
Publicado: (2015)

Integrative Analysis of Epigenome and Transcriptome Data Reveals Aberrantly Methylated Promoters and Enhancers in Hepatocellular Carcinoma
por: Huang, Peng, et al.
Publicado: (2021)

Transcriptome Profile of Next-Generation Sequencing Data Relate to Proliferation Aberration of Nasopharyngeal Carcinoma Patients in Indonesia
por: Setiasari, Dicka Wahyu, et al.
Publicado: (2020)

Identifying Key Genes for Nasopharyngeal Carcinoma by Prioritized Consensus Differentially Expressed Genes Caused by Aberrant Methylation
por: Chen, Yunqin, et al.
Publicado: (2021)

Aberrant DNA methylation in melanoma: biomarker and therapeutic opportunities
por: Micevic, Goran, et al.
Publicado: (2017)

Transcriptomic Analyses Reveal Gene Expression Profiles and Networks in Nasopharyngeal Carcinoma
por: Zhou, Yaqi, et al.
Publicado: (2021)

Diagnostic Value of DAPK Methylation for Nasopharyngeal Carcinoma: Meta-Analysis
por: Lao, Thuan Duc, et al.
Publicado: (2023)

Juvenile Nasopharyngeal Angiofibroma: An Aberrant Case Report
por: Jadhav, Swaragandha, et al.
Publicado: (2022)

Septin 9 Methylation in Nasopharyngeal Swabs: A Potential Minimally Invasive Biomarker for the Early Detection of Nasopharyngeal Carcinoma
por: Lyu, Jie-Yu, et al.
Publicado: (2020)

Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics
por: Ding, Ren-Bo, et al.
Publicado: (2021)

Comprehensive analysis of aberrantly expressed circRNAs, mRNAs and lncRNAs in patients with nasopharyngeal carcinoma
por: Guo, Feifan, et al.
Publicado: (2023)

DNA methylation biomarkers for nasopharyngeal carcinoma
por: Han, Baoai, et al.
Publicado: (2020)

Transcriptomic profiling revealed FZD10 as a novel biomarker for nasopharyngeal carcinoma recurrence
por: Tulalamba, Warut, et al.
Publicado: (2023)

Prognostic Value of Clinical Biochemistry-Based Indexes in Nasopharyngeal Carcinoma
por: Zeng, Xiaojiao, et al.
Publicado: (2020)

Whole-Exome Sequencing of Nasopharyngeal Carcinoma Families Reveals Novel Variants Potentially Involved in Nasopharyngeal Carcinoma
por: Yu, Guoqin, et al.
Publicado: (2019)

Aberrant DNA Methylation as a Biomarker and a Therapeutic Target of Cholangiocarcinoma
por: Nakaoka, Toshiaki, et al.
Publicado: (2017)

Transcriptome and methylome sequencing reveals altered long non-coding RNA genes expression and their aberrant DNA methylation in equine sarcoids
por: Semik-Gurgul, Ewelina, et al.
Publicado: (2023)

Epigenome-wide analysis of common warts reveals aberrant promoter methylation
por: AL-Eitan, Laith N., et al.
Publicado: (2020)

Multiscale Transcriptomic Integration Reveals B-Cell Depletion and T-Cell Mistrafficking in Nasopharyngeal Carcinoma Progression
por: Shi, Xiaojie, et al.
Publicado: (2022)

Inappropriate costimulation and aberrant DNA methylation as therapeutic targets in angioimmunoblastic T-cell lymphoma
por: Willemsen, Mathijs, et al.
Publicado: (2017)

Proteomics Profiling Reveals the Molecular Signatures and Potential Therapeutic Targets of Human Nasopharyngeal Carcinoma
por: Fu, Ying, et al.
Publicado: (2023)

The emergence of tumor-infiltrating lymphocytes in nasopharyngeal carcinoma: Predictive value and immunotherapy implications
por: Yang, Liu, et al.
Publicado: (2021)

Transcriptome sequencing of human breast cancer reveals aberrant intronic transcription in amplicons and dysregulation of alternative splicing with major therapeutic implications
Publicado: (2017)

Aberrant DNA Methylation in Keratoacanthoma
por: Nobeyama, Yoshimasa, et al.
Publicado: (2016)

DNA Methylation Aberrant in Atherosclerosis
por: Dai, Yao, et al.
Publicado: (2022)

Elucidating the Landscape of Aberrant DNA Methylation in Hepatocellular Carcinoma
por: Song, Min-Ae, et al.
Publicado: (2013)

An aberrant DNA methylation signature for predicting hepatocellular carcinoma
por: Zhang, Renhua, et al.
Publicado: (2020)

Epigenome profiling reveals aberrant DNA methylation signature in GATA2 deficiency
por: Marin-Bejar, Oskar, et al.
Publicado: (2023)

Identifying Apoptosis-Related Transcriptomic Aberrations and Revealing Clinical Relevance as Diagnostic and Prognostic Biomarker in Hepatocellular Carcinoma
por: Zhu, Jinyu, et al.
Publicado: (2021)

Aberrant Methylation of Aging-Related Genes in Asthma
por: Yang, Yu, et al.
Publicado: (2021)

Aberrant Methylation of Thrombospondin-1 and Its Association with Reduced Expression in Gastric Cardia Adenocarcinoma
por: Guo, Wei, et al.
Publicado: (2010)

DNA methylation mediates BmDeaf1-regulated tissue- and stage-specific expression of BmCHSA-2b in the silkworm, Bombyx mori
por: Xu, Guanfeng, et al.
Publicado: (2018)

Identification of candidate aberrantly methylated and differentially expressed genes in Esophageal squamous cell carcinoma
por: Han, Bao-Ai, et al.
Publicado: (2020)

MicroRNAs as Therapeutic Targets in Nasopharyngeal Carcinoma
por: Wang, Sumei, et al.
Publicado: (2019)

Development and validation of immune inflammation–based index for predicting the clinical outcome in patients with nasopharyngeal carcinoma
por: Zeng, Xiaojiao, et al.
Publicado: (2020)

Aberrant methylation of WD‐repeat protein 41 contributes to tumour progression in triple‐negative breast cancer
por: Wang, Han, et al.
Publicado: (2020)

Early Changes in Transcriptomic Profiles in Synaptodendrosomes Reveal Aberrant Synaptic Functions in Alzheimer’s Disease
por: Qu, Xueqi, et al.
Publicado: (2022)

Efficacy and safety of low concentration hydrogen peroxide as nasopharyngeal lavage fluid in the treatment for nasopharyngeal carcinoma radiotherapy: a pilot cohort study
por: Xiong, Juan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_r3258sdkcjipv3jl30r8q45j3f