Evaluation of SARS-CoV-2 Main Protease Inhibitors Using a Novel Cell-Based Assay

[Image: see text] As an essential enzyme of SARS-CoV-2, main protease (M(Pro)) triggers acute toxicity to its human cell host, an effect that can be alleviated by an M(Pro) inhibitor. Using this toxicity alleviation, we developed an effective method that allows a bulk analysis of the cellular potenc...

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Detalles Bibliográficos
Autores principales: Cao, Wenyue, Cho, Chia-Chuan Dean, Geng, Zhi Zachary, Shaabani, Namir, Ma, Xinyu R., Vatansever, Erol C., Alugubelli, Yugendar R., Ma, Yuying, Chaki, Sankar P., Ellenburg, William H., Yang, Kai S., Qiao, Yuchen, Allen, Robert, Neuman, Benjamin W., Ji, Henry, Xu, Shiqing, Liu, Wenshe Ray
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848508/
https://www.ncbi.nlm.nih.gov/pubmed/35229034
http://dx.doi.org/10.1021/acscentsci.1c00910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848508/
https://www.ncbi.nlm.nih.gov/pubmed/35229034
http://dx.doi.org/10.1021/acscentsci.1c00910

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