Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

[Image: see text] Drugs targeting SARS-CoV-2 could have saved millions of lives during the COVID-19 pandemic, and it is now crucial to develop inhibitors of coronavirus replication in preparation for future outbreaks. We explored two virtual screening strategies to find inhibitors of the SARS-CoV-2...

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Detalles Bibliográficos
Autores principales: Luttens, Andreas, Gullberg, Hjalmar, Abdurakhmanov, Eldar, Vo, Duy Duc, Akaberi, Dario, Talibov, Vladimir O., Nekhotiaeva, Natalia, Vangeel, Laura, De Jonghe, Steven, Jochmans, Dirk, Krambrich, Janina, Tas, Ali, Lundgren, Bo, Gravenfors, Ylva, Craig, Alexander J., Atilaw, Yoseph, Sandström, Anja, Moodie, Lindon W. K., Lundkvist, Åke, van Hemert, Martijn J., Neyts, Johan, Lennerstrand, Johan, Kihlberg, Jan, Sandberg, Kristian, Danielson, U. Helena, Carlsson, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848513/
https://www.ncbi.nlm.nih.gov/pubmed/35142215
http://dx.doi.org/10.1021/jacs.1c08402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848513/
https://www.ncbi.nlm.nih.gov/pubmed/35142215
http://dx.doi.org/10.1021/jacs.1c08402

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