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Anti-NMDA-receptor encephalitis: an unusual treatable cause of chronic insomnia?
We describe an unusual case of severe and chronic insomnia that proved to be eminently treatable. Initially presumed to be of primary psychiatric/toxicological origin, certain clinical and paraclinical clues led us to the diagnosis of NMDA-receptor encephalitis, an immune-mediated disease of the bra...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Brazilian Association of Sleep and Latin American Federation of Sleep
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848525/ https://www.ncbi.nlm.nih.gov/pubmed/35186210 http://dx.doi.org/10.5935/1984-0063.20200080 |
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author | Wiels, Wietse A. Boudiba, Yacine Seynaeve, Laura Raedt, Sylvie De |
author_facet | Wiels, Wietse A. Boudiba, Yacine Seynaeve, Laura Raedt, Sylvie De |
author_sort | Wiels, Wietse A. |
collection | PubMed |
description | We describe an unusual case of severe and chronic insomnia that proved to be eminently treatable. Initially presumed to be of primary psychiatric/toxicological origin, certain clinical and paraclinical clues led us to the diagnosis of NMDA-receptor encephalitis, an immune-mediated disease of the brain. Our patient responded dramatically to immunotherapy, effectively regaining normal sleep habits and significantly improving his general and mental health after 25 years of insomnia and drug abuse. Immune-mediated encephalopathies should be considered in the differential diagnosis of severe sleep disorders that present with additional neurological signs and symptoms, even when chronic. |
format | Online Article Text |
id | pubmed-8848525 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Brazilian Association of Sleep and Latin American Federation of Sleep |
record_format | MEDLINE/PubMed |
spelling | pubmed-88485252022-02-18 Anti-NMDA-receptor encephalitis: an unusual treatable cause of chronic insomnia? Wiels, Wietse A. Boudiba, Yacine Seynaeve, Laura Raedt, Sylvie De Sleep Sci Case Reports We describe an unusual case of severe and chronic insomnia that proved to be eminently treatable. Initially presumed to be of primary psychiatric/toxicological origin, certain clinical and paraclinical clues led us to the diagnosis of NMDA-receptor encephalitis, an immune-mediated disease of the brain. Our patient responded dramatically to immunotherapy, effectively regaining normal sleep habits and significantly improving his general and mental health after 25 years of insomnia and drug abuse. Immune-mediated encephalopathies should be considered in the differential diagnosis of severe sleep disorders that present with additional neurological signs and symptoms, even when chronic. Brazilian Association of Sleep and Latin American Federation of Sleep 2021 /pmc/articles/PMC8848525/ /pubmed/35186210 http://dx.doi.org/10.5935/1984-0063.20200080 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Reports Wiels, Wietse A. Boudiba, Yacine Seynaeve, Laura Raedt, Sylvie De Anti-NMDA-receptor encephalitis: an unusual treatable cause of chronic insomnia? |
title | Anti-NMDA-receptor encephalitis: an unusual treatable cause of chronic insomnia? |
title_full | Anti-NMDA-receptor encephalitis: an unusual treatable cause of chronic insomnia? |
title_fullStr | Anti-NMDA-receptor encephalitis: an unusual treatable cause of chronic insomnia? |
title_full_unstemmed | Anti-NMDA-receptor encephalitis: an unusual treatable cause of chronic insomnia? |
title_short | Anti-NMDA-receptor encephalitis: an unusual treatable cause of chronic insomnia? |
title_sort | anti-nmda-receptor encephalitis: an unusual treatable cause of chronic insomnia? |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848525/ https://www.ncbi.nlm.nih.gov/pubmed/35186210 http://dx.doi.org/10.5935/1984-0063.20200080 |
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