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The role of Monocyte Distribution Width (MDW) in the prognosis and monitoring of COVID-19 patients
The new parameter derived from the standard deviation of the monocyte distribution width (MDW) has shown a good diagnostic efficacy in COVID-19 patients. In this study, we propose MDW as a prognostic and monitoring parameter in patients with severe forms of COVID-19. Sixty SARS-CoV-2-positive patien...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Inc. on behalf of The Canadian Society of Clinical Chemists.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848545/ https://www.ncbi.nlm.nih.gov/pubmed/35182522 http://dx.doi.org/10.1016/j.clinbiochem.2022.02.007 |
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author | Lorubbio, Maria Tacconi, Danilo Iannelli, Giovanni Feri, Marco Scala, Raffaele Montemerani, Sara Mandò, Massimo Ognibene, Agostino |
author_facet | Lorubbio, Maria Tacconi, Danilo Iannelli, Giovanni Feri, Marco Scala, Raffaele Montemerani, Sara Mandò, Massimo Ognibene, Agostino |
author_sort | Lorubbio, Maria |
collection | PubMed |
description | The new parameter derived from the standard deviation of the monocyte distribution width (MDW) has shown a good diagnostic efficacy in COVID-19 patients. In this study, we propose MDW as a prognostic and monitoring parameter in patients with severe forms of COVID-19. Sixty SARS-CoV-2-positive patients admitted to the San Donato Hospital in Arezzo were enrolled. A blood sample taken to measure the complete blood count was used for the determination of MDW using a UniCel DxH 900 instrument (Beckman Coulter). For each patient, a mean of 6 ± 2 measurements of MDW were taken. The difference between the last and first MDW results was reported as the ΔMDW variable. The ΔMDW and age were significantly correlated to the outcome. In non-survivors patients, the difference in the mean of the MDW between the first and other points was not significant, while in survivors, the first point was higher than the other points (p < 0.005), with the exception of the mean of the second point (p-value = NS). The ΔMDW area under the curve (AUC) was 0.84, and with a cut-off lower than 0.00 the sensitivity and specificity were 88% and 81%, respectively. The most important result of this study is the ΔMDW calculated on the basis of the difference between the first and third measurement, after approximately the 5–7th day of hospitalisation. A ΔMDW less than one was indicative of an unfavourable prognosis. The data reported suggest that MDW could be used to support monitoring and surveillance, alongside other tests such as procalcitonin, in critically ill patients in the ICU. |
format | Online Article Text |
id | pubmed-8848545 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Published by Elsevier Inc. on behalf of The Canadian Society of Clinical Chemists. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88485452022-02-16 The role of Monocyte Distribution Width (MDW) in the prognosis and monitoring of COVID-19 patients Lorubbio, Maria Tacconi, Danilo Iannelli, Giovanni Feri, Marco Scala, Raffaele Montemerani, Sara Mandò, Massimo Ognibene, Agostino Clin Biochem Short Communication The new parameter derived from the standard deviation of the monocyte distribution width (MDW) has shown a good diagnostic efficacy in COVID-19 patients. In this study, we propose MDW as a prognostic and monitoring parameter in patients with severe forms of COVID-19. Sixty SARS-CoV-2-positive patients admitted to the San Donato Hospital in Arezzo were enrolled. A blood sample taken to measure the complete blood count was used for the determination of MDW using a UniCel DxH 900 instrument (Beckman Coulter). For each patient, a mean of 6 ± 2 measurements of MDW were taken. The difference between the last and first MDW results was reported as the ΔMDW variable. The ΔMDW and age were significantly correlated to the outcome. In non-survivors patients, the difference in the mean of the MDW between the first and other points was not significant, while in survivors, the first point was higher than the other points (p < 0.005), with the exception of the mean of the second point (p-value = NS). The ΔMDW area under the curve (AUC) was 0.84, and with a cut-off lower than 0.00 the sensitivity and specificity were 88% and 81%, respectively. The most important result of this study is the ΔMDW calculated on the basis of the difference between the first and third measurement, after approximately the 5–7th day of hospitalisation. A ΔMDW less than one was indicative of an unfavourable prognosis. The data reported suggest that MDW could be used to support monitoring and surveillance, alongside other tests such as procalcitonin, in critically ill patients in the ICU. Published by Elsevier Inc. on behalf of The Canadian Society of Clinical Chemists. 2022-05 2022-02-16 /pmc/articles/PMC8848545/ /pubmed/35182522 http://dx.doi.org/10.1016/j.clinbiochem.2022.02.007 Text en © 2022 Published by Elsevier Inc. on behalf of The Canadian Society of Clinical Chemists. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Short Communication Lorubbio, Maria Tacconi, Danilo Iannelli, Giovanni Feri, Marco Scala, Raffaele Montemerani, Sara Mandò, Massimo Ognibene, Agostino The role of Monocyte Distribution Width (MDW) in the prognosis and monitoring of COVID-19 patients |
title | The role of Monocyte Distribution Width (MDW) in the prognosis and monitoring of COVID-19 patients |
title_full | The role of Monocyte Distribution Width (MDW) in the prognosis and monitoring of COVID-19 patients |
title_fullStr | The role of Monocyte Distribution Width (MDW) in the prognosis and monitoring of COVID-19 patients |
title_full_unstemmed | The role of Monocyte Distribution Width (MDW) in the prognosis and monitoring of COVID-19 patients |
title_short | The role of Monocyte Distribution Width (MDW) in the prognosis and monitoring of COVID-19 patients |
title_sort | role of monocyte distribution width (mdw) in the prognosis and monitoring of covid-19 patients |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848545/ https://www.ncbi.nlm.nih.gov/pubmed/35182522 http://dx.doi.org/10.1016/j.clinbiochem.2022.02.007 |
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