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Epidemiological theory of virus variants
We propose a physics-inspired mathematical model underlying the temporal evolution of competing virus variants that relies on the existence of (quasi) fixed points capturing the large time scale invariance of the dynamics. To motivate our result we first modify the time-honoured compartmental models...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848575/ https://www.ncbi.nlm.nih.gov/pubmed/35185268 http://dx.doi.org/10.1016/j.physa.2022.127071 |
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author | Cacciapaglia, Giacomo Cot, Corentin de Hoffer, Adele Hohenegger, Stefan Sannino, Francesco Vatani, Shahram |
author_facet | Cacciapaglia, Giacomo Cot, Corentin de Hoffer, Adele Hohenegger, Stefan Sannino, Francesco Vatani, Shahram |
author_sort | Cacciapaglia, Giacomo |
collection | PubMed |
description | We propose a physics-inspired mathematical model underlying the temporal evolution of competing virus variants that relies on the existence of (quasi) fixed points capturing the large time scale invariance of the dynamics. To motivate our result we first modify the time-honoured compartmental models of the SIR type to account for the existence of competing variants and then show how their evolution can be naturally re-phrased in terms of flow equations ending at quasi fixed points. As the natural next step we employ (near) scale invariance to organise the time evolution of the competing variants within the effective description of the epidemic Renormalisation Group framework. We test the resulting theory against the time evolution of COVID-19 virus variants that validate the theory empirically. |
format | Online Article Text |
id | pubmed-8848575 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88485752022-02-16 Epidemiological theory of virus variants Cacciapaglia, Giacomo Cot, Corentin de Hoffer, Adele Hohenegger, Stefan Sannino, Francesco Vatani, Shahram Physica A Article We propose a physics-inspired mathematical model underlying the temporal evolution of competing virus variants that relies on the existence of (quasi) fixed points capturing the large time scale invariance of the dynamics. To motivate our result we first modify the time-honoured compartmental models of the SIR type to account for the existence of competing variants and then show how their evolution can be naturally re-phrased in terms of flow equations ending at quasi fixed points. As the natural next step we employ (near) scale invariance to organise the time evolution of the competing variants within the effective description of the epidemic Renormalisation Group framework. We test the resulting theory against the time evolution of COVID-19 virus variants that validate the theory empirically. Elsevier B.V. 2022-06-15 2022-02-16 /pmc/articles/PMC8848575/ /pubmed/35185268 http://dx.doi.org/10.1016/j.physa.2022.127071 Text en © 2022 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Cacciapaglia, Giacomo Cot, Corentin de Hoffer, Adele Hohenegger, Stefan Sannino, Francesco Vatani, Shahram Epidemiological theory of virus variants |
title | Epidemiological theory of virus variants |
title_full | Epidemiological theory of virus variants |
title_fullStr | Epidemiological theory of virus variants |
title_full_unstemmed | Epidemiological theory of virus variants |
title_short | Epidemiological theory of virus variants |
title_sort | epidemiological theory of virus variants |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848575/ https://www.ncbi.nlm.nih.gov/pubmed/35185268 http://dx.doi.org/10.1016/j.physa.2022.127071 |
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