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Dopamine signaling modulates microglial NLRP3 inflammasome activation: implications for Parkinson’s disease

BACKGROUND: Parkinson’s disease (PD) is characterized by the loss of nigral dopaminergic neurons leading to impaired striatal dopamine signaling, α-synuclein- (α-syn-) rich inclusions, and neuroinflammation. Degenerating neurons are surrounded by activated microglia with increased secretion of inter...

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Detalles Bibliográficos
Autores principales:	Pike, Adrianne F., Longhena, Francesca, Faustini, Gaia, van Eik, Jean-Marc, Gombert, Iris, Herrebout, Maaike A. C., Fayed, Mona M. H. E., Sandre, Michele, Varanita, Tatiana, Teunissen, Charlotte E., Hoozemans, Jeroen J. M., Bellucci, Arianna, Veerhuis, Robert, Bubacco, Luigi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848816/ https://www.ncbi.nlm.nih.gov/pubmed/35172843 http://dx.doi.org/10.1186/s12974-022-02410-4

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