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Metastatic mucoepidermoid carcinoma to the pleura: a case report

BACKGROUND: Mucoepidermoid carcinoma is the most common malignant neoplasm arising from the salivary glands (Ali et al. in J Ayub Med Coll Abbottabad 20(2): 141-2, 2008, Xi et al. in World J Surg Oncol 10: 232, 2012). When arising from anatomic sites other than the salivary glands it can be a diagno...

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Autores principales: Mashiana, Simran, Duarte, Ernesto Martinez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848957/
https://www.ncbi.nlm.nih.gov/pubmed/35168684
http://dx.doi.org/10.1186/s13256-022-03285-y
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author Mashiana, Simran
Duarte, Ernesto Martinez
author_facet Mashiana, Simran
Duarte, Ernesto Martinez
author_sort Mashiana, Simran
collection PubMed
description BACKGROUND: Mucoepidermoid carcinoma is the most common malignant neoplasm arising from the salivary glands (Ali et al. in J Ayub Med Coll Abbottabad 20(2): 141-2, 2008, Xi et al. in World J Surg Oncol 10: 232, 2012). When arising from anatomic sites other than the salivary glands it can be a diagnostic challenge. Primary and metastatic mucoepidermoid carcinoma from and to the pleura are extremely rare entities that are frequently misdiagnosed as adenocarcinoma, adenosquamous carcinoma, or squamous cell carcinoma (Xi et al. in World J Surg Oncol 10: 232, 2012). CASE PRESENTATION: We describe an unusual case of a 64-year-old Caucasian female patient with metastatic high-grade mucoepidermoid carcinoma to the pleura, morphologically resembling squamous cell carcinoma. Molecular studies of both the parotid gland and pleural tumors helped prove the metastatic nature of the pleural lesion. CONCLUSIONS:  Metastatic mucoepidermoid carcinoma to the pleura is a rare entity, frequently misdiagnosed as squamous cell carcinoma. Differentiating between a lung primary and a metastatic disease has treatment implications and prognostic significance for the patient. When morphologic and immunophenotypic overlap exists, molecular testing can help distinguish mucoepidermoid carcinoma from other neoplasms.
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spelling pubmed-88489572022-02-18 Metastatic mucoepidermoid carcinoma to the pleura: a case report Mashiana, Simran Duarte, Ernesto Martinez J Med Case Rep Case Report BACKGROUND: Mucoepidermoid carcinoma is the most common malignant neoplasm arising from the salivary glands (Ali et al. in J Ayub Med Coll Abbottabad 20(2): 141-2, 2008, Xi et al. in World J Surg Oncol 10: 232, 2012). When arising from anatomic sites other than the salivary glands it can be a diagnostic challenge. Primary and metastatic mucoepidermoid carcinoma from and to the pleura are extremely rare entities that are frequently misdiagnosed as adenocarcinoma, adenosquamous carcinoma, or squamous cell carcinoma (Xi et al. in World J Surg Oncol 10: 232, 2012). CASE PRESENTATION: We describe an unusual case of a 64-year-old Caucasian female patient with metastatic high-grade mucoepidermoid carcinoma to the pleura, morphologically resembling squamous cell carcinoma. Molecular studies of both the parotid gland and pleural tumors helped prove the metastatic nature of the pleural lesion. CONCLUSIONS:  Metastatic mucoepidermoid carcinoma to the pleura is a rare entity, frequently misdiagnosed as squamous cell carcinoma. Differentiating between a lung primary and a metastatic disease has treatment implications and prognostic significance for the patient. When morphologic and immunophenotypic overlap exists, molecular testing can help distinguish mucoepidermoid carcinoma from other neoplasms. BioMed Central 2022-02-16 /pmc/articles/PMC8848957/ /pubmed/35168684 http://dx.doi.org/10.1186/s13256-022-03285-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Mashiana, Simran
Duarte, Ernesto Martinez
Metastatic mucoepidermoid carcinoma to the pleura: a case report
title Metastatic mucoepidermoid carcinoma to the pleura: a case report
title_full Metastatic mucoepidermoid carcinoma to the pleura: a case report
title_fullStr Metastatic mucoepidermoid carcinoma to the pleura: a case report
title_full_unstemmed Metastatic mucoepidermoid carcinoma to the pleura: a case report
title_short Metastatic mucoepidermoid carcinoma to the pleura: a case report
title_sort metastatic mucoepidermoid carcinoma to the pleura: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848957/
https://www.ncbi.nlm.nih.gov/pubmed/35168684
http://dx.doi.org/10.1186/s13256-022-03285-y
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