Cargando…
Converting the E. coli Isochorismatase Nicotinamidase into γ-Lactamase
Nicotinamidase (Nic) (E.C.3.5.1.19) is a representative protein of the isochorismatase superfamily from Escherichia coli. Despite showing no (+) γ-lactamase activity, its active site constellations (ASCs) are very similar to those of two other known (+) γ-lactamases (Mhpg and RutB), indicating that...
Autores principales: | Guo, Xiaoyan, Chang, Licao, Jin, Haibo, Zhu, Junge, Tao, Yong, Wu, Sheng, Wang, Jianjun |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849098/ https://www.ncbi.nlm.nih.gov/pubmed/35171012 http://dx.doi.org/10.1128/spectrum.00985-21 |
Ejemplares similares
-
Structural insights into the γ-lactamase activity and substrate enantioselectivity of an isochorismatase-like hydrolase from Microbacterium hydrocarbonoxydans
por: Gao, Shuaihua, et al.
Publicado: (2017) -
Metallochaperones Are Needed for Mycobacterium tuberculosis and Escherichia coli Nicotinamidase-Pyrazinamidase Activity
por: Sheen, Patricia, et al.
Publicado: (2020) -
CBD binding domain fused γ-lactamase from Sulfolobus solfataricus is an efficient catalyst for (-) γ-lactam production
por: Wang, Jianjun, et al.
Publicado: (2014) -
Plasmodium falciparum Nicotinamidase as A Novel Antimalarial Target
por: Donu, Dickson, et al.
Publicado: (2022) -
Molecular Dynamics Simulations Suggest Ligand’s Binding to Nicotinamidase/Pyrazinamidase
por: Zhang, Ji-Long, et al.
Publicado: (2012)