NOTCH1 PEST domain variants are responsive to standard of care treatments despite distinct transformative properties in a breast cancer model

Activating variants in the PEST region of NOTCH1 have been associated with aggressive phenotypes in human cancers, including triple-negative breast cancer (TNBC). Previous studies suggested that PEST domain variants in TNBC patients resulted in increased cell proliferation, invasiveness, and decreas...

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Detalles Bibliográficos
Autores principales: Cravero, Karen, Pantone, Morgan V., Shin, Dong Ho, Bergman, Riley, Cochran, Rory, Chu, David, Zabransky, Daniel J., Karthikeyan, Swathi, Waters, Ian G., Hunter, Natasha, Rosen, D. Marc, Kyker-Snowman, Kelly, Dalton, W. Brian, Button, Berry, Shinn, Dan, Wong, Hong Yuen, Donaldson, Joshua, Hurley, Paula J., Croessmann, Sarah, Park, Ben Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849273/
https://www.ncbi.nlm.nih.gov/pubmed/35186194
http://dx.doi.org/10.18632/oncotarget.28200

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