Ultrarapid lytic granule release from CTLs activates Ca(2+)-dependent synaptic resistance pathways in melanoma cells

Human cytotoxic T lymphocytes (CTLs) exhibit ultrarapid lytic granule secretion, but whether melanoma cells mobilize defense mechanisms with commensurate rapidity remains unknown. We used single-cell time-lapse microscopy to offer high spatiotemporal resolution analyses of subcellular events in mela...

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Detalles Bibliográficos
Autores principales: Filali, Liza, Puissegur, Marie-Pierre, Cortacero, Kevin, Cussat-Blanc, Sylvain, Khazen, Roxana, Van Acker, Nathalie, Frenois, François-Xavier, Abreu, Arnaud, Lamant, Laurence, Meyer, Nicolas, Vergier, Béatrice, Müller, Sabina, McKenzie, Brienne, Valitutti, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849291/
https://www.ncbi.nlm.nih.gov/pubmed/35171665
http://dx.doi.org/10.1126/sciadv.abk3234

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