A balanced Oct4 interactome is crucial for maintaining pluripotency

Oct4 collaborates primarily with other transcriptional factors or coregulators to maintain pluripotency. However, how Oct4 exerts its function is still unclear. Here, we show that the Oct4 linker interface mediates competing yet balanced Oct4 protein interactions that are crucial for maintaining plu...

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Detalles Bibliográficos
Autores principales: Han, Dong, Wu, Guangming, Chen, Rui, Drexler, Hannes C. A., MacCarthy, Caitlin M., Kim, Kee-Pyo, Adachi, Kenjiro, Gerovska, Daniela, Mavrommatis, Lampros, Bedzhov, Ivan, Araúzo-Bravo, Marcos J., Schöler, Hans R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849292/
https://www.ncbi.nlm.nih.gov/pubmed/35171666
http://dx.doi.org/10.1126/sciadv.abe4375

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