Efficient healing of large osseous segmental defects using optimized chemically modified messenger RNA encoding BMP-2

Large segmental osseous defects heal poorly. Recombinant, human bone morphogenetic protein-2 (rhBMP-2) is used clinically to promote bone healing, but it is applied at very high doses that cause adverse side effects and raise costs while providing only incremental benefit. We describe a previously u...

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Detalles Bibliográficos
Autores principales: De La Vega, Rodolfo E., van Griensven, Martijn, Zhang, Wen, Coenen, Michael J., Nagelli, Christopher V., Panos, Joseph A., Peniche Silva, Carlos J., Geiger, Johannes, Plank, Christian, Evans, Christopher H., Balmayor, Elizabeth R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849297/
https://www.ncbi.nlm.nih.gov/pubmed/35171668
http://dx.doi.org/10.1126/sciadv.abl6242

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