Thermostable ionizable lipid-like nanoparticle (iLAND) for RNAi treatment of hyperlipidemia

Small interfering RNA (siRNA) therapeutic is considered to be a promising modality for the treatment of hyperlipidemia. Establishment of a thermostable clinically applicable delivery system remains a most challenging issue for siRNA drug development. Here, a series of ionizable lipid-like materials...

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Detalles Bibliográficos
Autores principales: Hu, Bo, Li, Bo, Li, Kun, Liu, Yuanyuan, Li, Chunhui, Zheng, Lulu, Zhang, Mengjie, Yang, Tongren, Guo, Shuai, Dong, Xiyu, Zhang, Tian, Liu, Qing, Hussain, Abid, Weng, Yuhua, Peng, Ling, Zhao, Yongxiang, Liang, Xing-Jie, Huang, Yuanyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849333/
https://www.ncbi.nlm.nih.gov/pubmed/35171673
http://dx.doi.org/10.1126/sciadv.abm1418

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