Extent, impact, and mitigation of batch effects in tumor biomarker studies using tissue microarrays

Tissue microarrays (TMAs) have been used in thousands of cancer biomarker studies. To what extent batch effects, measurement error in biomarker levels between slides, affects TMA-based studies has not been assessed systematically. We evaluated 20 protein biomarkers on 14 TMAs with prospectively coll...

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Detalles Bibliográficos
Autores principales: Stopsack, Konrad H, Tyekucheva, Svitlana, Wang, Molin, Gerke, Travis A, Vaselkiv, J Bailey, Penney, Kathryn L, Kantoff, Philip W, Finn, Stephen P, Fiorentino, Michelangelo, Loda, Massimo, Lotan, Tamara L, Parmigiani, Giovanni, Mucci, Lorelei A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849344/
https://www.ncbi.nlm.nih.gov/pubmed/34939926
http://dx.doi.org/10.7554/eLife.71265

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