P06 Pharmacokinetics and renal accumulation of VRP-034

BACKGROUND: Nephrotoxicity is a dose-limiting factor for polymyxin B (PMB), a last-line therapy for MDR Gram-negative bacterial infections. The majority of the filtered PMB undergoes extensive tubular reabsorption leading to significant accumulation of the drug in tubular cells, causing renal tubula...

Descripción completa

Detalles Bibliográficos
Autores principales: Vishwakarma, Kamlesh Kumar, Chilbule, Rahul, Chaudhary, Manu, Sharma, Arun, Chaudhary, Saransh, Aggarwal, Anmol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Posters Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849352/
http://dx.doi.org/10.1093/jacamr/dlac004.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849352/
http://dx.doi.org/10.1093/jacamr/dlac004.005

Ejemplares similares