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P48 The limited yield of cultures in the critically ill child
BACKGROUND: Broad-spectrum antimicrobial therapy is a key driver of antimicrobial resistance. Here, we aimed to review indications for antimicrobial therapy, determine the proportion of suspected bacterial infections that are confirmed by culture, and assess the time taken for microbiology test resu...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849361/ http://dx.doi.org/10.1093/jacamr/dlac004.047 |
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author | Clark, John White, Deborah Daubney, Esther Curran, Martin Bousfield, Rachel Gouliouris, Theodore Powell, Elizabeth Palmer, Adam Agrawal, Shruti Inwald, David Kean, Iain Török, M. Estée Baker, Stephen Pathan, Nazima |
author_facet | Clark, John White, Deborah Daubney, Esther Curran, Martin Bousfield, Rachel Gouliouris, Theodore Powell, Elizabeth Palmer, Adam Agrawal, Shruti Inwald, David Kean, Iain Török, M. Estée Baker, Stephen Pathan, Nazima |
author_sort | Clark, John |
collection | PubMed |
description | BACKGROUND: Broad-spectrum antimicrobial therapy is a key driver of antimicrobial resistance. Here, we aimed to review indications for antimicrobial therapy, determine the proportion of suspected bacterial infections that are confirmed by culture, and assess the time taken for microbiology test results to become available in the paediatric ICU (PICU). METHODS: A single-centre prospective observational cohort study of 100 consecutive general PICU admissions from 30 October 2019 to 19 February 2020. Data were collected from the hospital medical record and entered into a study database prior to statistical analysis using standard methods. RESULTS: Of all episodes of suspected infection, 22% of lower respiratory tract infection, 43% of bloodstream and 0% of central nervous system infection were associated with growth on microbiology culture. Ninety percent of children received antimicrobial therapy. Hospital-acquired infection occurred less commonly than primary infection, but an organism was grown in a greater proportion (64%) of cultures. Final laboratory reports for negative cultures were issued at a median of 120.3 h for blood cultures and 55.5 h for endotracheal tube aspirate cultures. CONCLUSIONS: Despite most critically children receiving antimicrobial therapy, infection was often not microbiologically confirmed. Novel molecular diagnostics may improve rationalization of treatment in this population. |
format | Online Article Text |
id | pubmed-8849361 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-88493612022-02-17 P48 The limited yield of cultures in the critically ill child Clark, John White, Deborah Daubney, Esther Curran, Martin Bousfield, Rachel Gouliouris, Theodore Powell, Elizabeth Palmer, Adam Agrawal, Shruti Inwald, David Kean, Iain Török, M. Estée Baker, Stephen Pathan, Nazima JAC Antimicrob Resist Posters Abstracts BACKGROUND: Broad-spectrum antimicrobial therapy is a key driver of antimicrobial resistance. Here, we aimed to review indications for antimicrobial therapy, determine the proportion of suspected bacterial infections that are confirmed by culture, and assess the time taken for microbiology test results to become available in the paediatric ICU (PICU). METHODS: A single-centre prospective observational cohort study of 100 consecutive general PICU admissions from 30 October 2019 to 19 February 2020. Data were collected from the hospital medical record and entered into a study database prior to statistical analysis using standard methods. RESULTS: Of all episodes of suspected infection, 22% of lower respiratory tract infection, 43% of bloodstream and 0% of central nervous system infection were associated with growth on microbiology culture. Ninety percent of children received antimicrobial therapy. Hospital-acquired infection occurred less commonly than primary infection, but an organism was grown in a greater proportion (64%) of cultures. Final laboratory reports for negative cultures were issued at a median of 120.3 h for blood cultures and 55.5 h for endotracheal tube aspirate cultures. CONCLUSIONS: Despite most critically children receiving antimicrobial therapy, infection was often not microbiologically confirmed. Novel molecular diagnostics may improve rationalization of treatment in this population. Oxford University Press 2022-02-16 /pmc/articles/PMC8849361/ http://dx.doi.org/10.1093/jacamr/dlac004.047 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Posters Abstracts Clark, John White, Deborah Daubney, Esther Curran, Martin Bousfield, Rachel Gouliouris, Theodore Powell, Elizabeth Palmer, Adam Agrawal, Shruti Inwald, David Kean, Iain Török, M. Estée Baker, Stephen Pathan, Nazima P48 The limited yield of cultures in the critically ill child |
title | P48 The limited yield of cultures in the critically ill child |
title_full | P48 The limited yield of cultures in the critically ill child |
title_fullStr | P48 The limited yield of cultures in the critically ill child |
title_full_unstemmed | P48 The limited yield of cultures in the critically ill child |
title_short | P48 The limited yield of cultures in the critically ill child |
title_sort | p48 the limited yield of cultures in the critically ill child |
topic | Posters Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849361/ http://dx.doi.org/10.1093/jacamr/dlac004.047 |
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