Arrested crossover precursor structures form stable homologous bonds in a Tetrahymena meiotic mutant

Meiotic DNA double-strand breaks produce reciprocally exchanged DNA strands, which mature into chiasmata that hold homologous chromosomes together as bivalents. These bivalents are subsequently separated in the first meiotic division. In a mutant lacking the newly identified Tetrahymena gene APRO1 (...

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Detalles Bibliográficos
Autores principales: Tian, Miao, Mochizuki, Kazufumi, Loidl, Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849441/
https://www.ncbi.nlm.nih.gov/pubmed/35171923
http://dx.doi.org/10.1371/journal.pone.0263691
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author Tian, Miao
Mochizuki, Kazufumi
Loidl, Josef
author_facet Tian, Miao
Mochizuki, Kazufumi
Loidl, Josef
author_sort Tian, Miao
collection PubMed
description Meiotic DNA double-strand breaks produce reciprocally exchanged DNA strands, which mature into chiasmata that hold homologous chromosomes together as bivalents. These bivalents are subsequently separated in the first meiotic division. In a mutant lacking the newly identified Tetrahymena gene APRO1 (Anaphase promoting 1), meiosis is arrested by the end of prophase. Mature chiasmata are not formed but bivalents are connected via a molecular precursor structure. In-depth analysis of this arrested intermediate structure may help to elucidate the noncanonical molecular recombination pathway in Tetrahymena.
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spelling pubmed-88494412022-02-17 Arrested crossover precursor structures form stable homologous bonds in a Tetrahymena meiotic mutant Tian, Miao Mochizuki, Kazufumi Loidl, Josef PLoS One Research Article Meiotic DNA double-strand breaks produce reciprocally exchanged DNA strands, which mature into chiasmata that hold homologous chromosomes together as bivalents. These bivalents are subsequently separated in the first meiotic division. In a mutant lacking the newly identified Tetrahymena gene APRO1 (Anaphase promoting 1), meiosis is arrested by the end of prophase. Mature chiasmata are not formed but bivalents are connected via a molecular precursor structure. In-depth analysis of this arrested intermediate structure may help to elucidate the noncanonical molecular recombination pathway in Tetrahymena. Public Library of Science 2022-02-16 /pmc/articles/PMC8849441/ /pubmed/35171923 http://dx.doi.org/10.1371/journal.pone.0263691 Text en © 2022 Tian et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Tian, Miao
Mochizuki, Kazufumi
Loidl, Josef
Arrested crossover precursor structures form stable homologous bonds in a Tetrahymena meiotic mutant
title Arrested crossover precursor structures form stable homologous bonds in a Tetrahymena meiotic mutant
title_full Arrested crossover precursor structures form stable homologous bonds in a Tetrahymena meiotic mutant
title_fullStr Arrested crossover precursor structures form stable homologous bonds in a Tetrahymena meiotic mutant
title_full_unstemmed Arrested crossover precursor structures form stable homologous bonds in a Tetrahymena meiotic mutant
title_short Arrested crossover precursor structures form stable homologous bonds in a Tetrahymena meiotic mutant
title_sort arrested crossover precursor structures form stable homologous bonds in a tetrahymena meiotic mutant
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849441/
https://www.ncbi.nlm.nih.gov/pubmed/35171923
http://dx.doi.org/10.1371/journal.pone.0263691
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AT loidljosef arrestedcrossoverprecursorstructuresformstablehomologousbondsinatetrahymenameioticmutant

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