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Cardiac Autonomic Modulation in Subjects with Amyotrophic Lateral Sclerosis (ALS) during an Upper Limb Virtual Reality Task: A Prospective Control Trial

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. As a result of the rapid progression and severity of the disease, people with ALS experience loss of functionality and independence. Furthermore, it has already been described presence of autonomic dysfunction. Despite the increasin...

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Autores principales: Silveira, Ana C., Moraes, Íbis A. P., Vidigal, Giovanna P., Simcsik, Amanda O., Rosa, Renata M., Favero, Francis M., Fernandes, Susi M. S., Garner, David M., Araújo, Luciano V., Massa, Marcelo, Vanderlei, Luiz C. M., Silva, Talita D., Monteiro, Carlos B. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850030/
https://www.ncbi.nlm.nih.gov/pubmed/35187164
http://dx.doi.org/10.1155/2022/4439681
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author Silveira, Ana C.
Moraes, Íbis A. P.
Vidigal, Giovanna P.
Simcsik, Amanda O.
Rosa, Renata M.
Favero, Francis M.
Fernandes, Susi M. S.
Garner, David M.
Araújo, Luciano V.
Massa, Marcelo
Vanderlei, Luiz C. M.
Silva, Talita D.
Monteiro, Carlos B. M.
author_facet Silveira, Ana C.
Moraes, Íbis A. P.
Vidigal, Giovanna P.
Simcsik, Amanda O.
Rosa, Renata M.
Favero, Francis M.
Fernandes, Susi M. S.
Garner, David M.
Araújo, Luciano V.
Massa, Marcelo
Vanderlei, Luiz C. M.
Silva, Talita D.
Monteiro, Carlos B. M.
author_sort Silveira, Ana C.
collection PubMed
description Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. As a result of the rapid progression and severity of the disease, people with ALS experience loss of functionality and independence. Furthermore, it has already been described presence of autonomic dysfunction. Despite the increasing use of virtual reality (VR) in the treatment of different diseases, the use of virtual reality environment as an intervention program for ALS patients is innovative. The benefits and limitations have not yet been proven. Our objective was to evaluate the autonomic function of individuals with amyotrophic lateral sclerosis throughout the virtual reality task. The analysis of autonomic function was completed before, during, and after the virtual reality task using the upper limbs; also, all steps lasted ten minutes in a sitting position. Heart rate variability (HRV) was taken via the Polar® RS800CX cardiofrequencymeter. The following questionnaire was enforced: Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS) and Fatigue Severity Scale (FSS). Different types of HRV were revealed for the groups, indicating that the ALS group has reduced HRV, with most of the representative indices of the sympathetic nervous system. Besides, the physiological process of reducing parasympathetic activity from rest to VR activity (vagal withdrawal), with reduction in HF (ms(2)) and an increase in HR from rest to activity, and a further increase throughout recovery, with withdrawal of sympathetic nervous system, occurs just for the control group (CG), with no alterations between rest, activity, and recovery in individuals with ALS. We could conclude that patients with ALS have the reduction of HRV with the sympathetic predominance when equated to the healthy CG. Besides that, the ALS individuals have no capability to adapt the autonomic nervous system when likened to the CG during therapy based on VR and their recovery.
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spelling pubmed-88500302022-02-17 Cardiac Autonomic Modulation in Subjects with Amyotrophic Lateral Sclerosis (ALS) during an Upper Limb Virtual Reality Task: A Prospective Control Trial Silveira, Ana C. Moraes, Íbis A. P. Vidigal, Giovanna P. Simcsik, Amanda O. Rosa, Renata M. Favero, Francis M. Fernandes, Susi M. S. Garner, David M. Araújo, Luciano V. Massa, Marcelo Vanderlei, Luiz C. M. Silva, Talita D. Monteiro, Carlos B. M. Biomed Res Int Research Article Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. As a result of the rapid progression and severity of the disease, people with ALS experience loss of functionality and independence. Furthermore, it has already been described presence of autonomic dysfunction. Despite the increasing use of virtual reality (VR) in the treatment of different diseases, the use of virtual reality environment as an intervention program for ALS patients is innovative. The benefits and limitations have not yet been proven. Our objective was to evaluate the autonomic function of individuals with amyotrophic lateral sclerosis throughout the virtual reality task. The analysis of autonomic function was completed before, during, and after the virtual reality task using the upper limbs; also, all steps lasted ten minutes in a sitting position. Heart rate variability (HRV) was taken via the Polar® RS800CX cardiofrequencymeter. The following questionnaire was enforced: Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS) and Fatigue Severity Scale (FSS). Different types of HRV were revealed for the groups, indicating that the ALS group has reduced HRV, with most of the representative indices of the sympathetic nervous system. Besides, the physiological process of reducing parasympathetic activity from rest to VR activity (vagal withdrawal), with reduction in HF (ms(2)) and an increase in HR from rest to activity, and a further increase throughout recovery, with withdrawal of sympathetic nervous system, occurs just for the control group (CG), with no alterations between rest, activity, and recovery in individuals with ALS. We could conclude that patients with ALS have the reduction of HRV with the sympathetic predominance when equated to the healthy CG. Besides that, the ALS individuals have no capability to adapt the autonomic nervous system when likened to the CG during therapy based on VR and their recovery. Hindawi 2022-02-09 /pmc/articles/PMC8850030/ /pubmed/35187164 http://dx.doi.org/10.1155/2022/4439681 Text en Copyright © 2022 Ana C. Silveira et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Silveira, Ana C.
Moraes, Íbis A. P.
Vidigal, Giovanna P.
Simcsik, Amanda O.
Rosa, Renata M.
Favero, Francis M.
Fernandes, Susi M. S.
Garner, David M.
Araújo, Luciano V.
Massa, Marcelo
Vanderlei, Luiz C. M.
Silva, Talita D.
Monteiro, Carlos B. M.
Cardiac Autonomic Modulation in Subjects with Amyotrophic Lateral Sclerosis (ALS) during an Upper Limb Virtual Reality Task: A Prospective Control Trial
title Cardiac Autonomic Modulation in Subjects with Amyotrophic Lateral Sclerosis (ALS) during an Upper Limb Virtual Reality Task: A Prospective Control Trial
title_full Cardiac Autonomic Modulation in Subjects with Amyotrophic Lateral Sclerosis (ALS) during an Upper Limb Virtual Reality Task: A Prospective Control Trial
title_fullStr Cardiac Autonomic Modulation in Subjects with Amyotrophic Lateral Sclerosis (ALS) during an Upper Limb Virtual Reality Task: A Prospective Control Trial
title_full_unstemmed Cardiac Autonomic Modulation in Subjects with Amyotrophic Lateral Sclerosis (ALS) during an Upper Limb Virtual Reality Task: A Prospective Control Trial
title_short Cardiac Autonomic Modulation in Subjects with Amyotrophic Lateral Sclerosis (ALS) during an Upper Limb Virtual Reality Task: A Prospective Control Trial
title_sort cardiac autonomic modulation in subjects with amyotrophic lateral sclerosis (als) during an upper limb virtual reality task: a prospective control trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850030/
https://www.ncbi.nlm.nih.gov/pubmed/35187164
http://dx.doi.org/10.1155/2022/4439681
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