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Destructive and topical treatments of skin lesions in organ transplant recipients and relation to skin cancer

Various treatments of keratotic skin lesions and early skin cancers are performed in organ transplant recipients (OTRs) at high risk of skin malignancies but the frequency of their use is unknown. We prospectively assessed the frequency of use of cryotherapy, diathermy, and topical therapies and als...

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Autores principales: Green, Adele C., Way, Mandy, Oster, Mariella, Plasmeijer, Elsemieke I., Jiyad, Zainab, O’Rourke, Peter, Miura, Kyoko, Campbell, Scott, Isbel, Nicole, Chambers, Daniel C., Hopkins, Peter, Ferguson, Lisa E., Davis, Marcia Batista, Whiteman, David C., Soyer, H. Peter, Marquart, Louise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850214/
https://www.ncbi.nlm.nih.gov/pubmed/32889576
http://dx.doi.org/10.1007/s00403-020-02136-4
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author Green, Adele C.
Way, Mandy
Oster, Mariella
Plasmeijer, Elsemieke I.
Jiyad, Zainab
O’Rourke, Peter
Miura, Kyoko
Campbell, Scott
Isbel, Nicole
Chambers, Daniel C.
Hopkins, Peter
Ferguson, Lisa E.
Davis, Marcia Batista
Whiteman, David C.
Soyer, H. Peter
Marquart, Louise
author_facet Green, Adele C.
Way, Mandy
Oster, Mariella
Plasmeijer, Elsemieke I.
Jiyad, Zainab
O’Rourke, Peter
Miura, Kyoko
Campbell, Scott
Isbel, Nicole
Chambers, Daniel C.
Hopkins, Peter
Ferguson, Lisa E.
Davis, Marcia Batista
Whiteman, David C.
Soyer, H. Peter
Marquart, Louise
author_sort Green, Adele C.
collection PubMed
description Various treatments of keratotic skin lesions and early skin cancers are performed in organ transplant recipients (OTRs) at high risk of skin malignancies but the frequency of their use is unknown. We prospectively assessed the frequency of use of cryotherapy, diathermy, and topical therapies and also investigated their associations with background incidence of histologically-confirmed squamous-cell carcinoma (SCC) and basal cell carcinoma (BCC) in a cohort of OTRs in Queensland, Australia. Median follow-up ranged from 1.7 to 3.2 years across organ transplant groups. Among 285 kidney, 125 lung and 203 liver transplant recipients [382 (62%) male, 380 (62%) immunosuppressed > 5 years, 394 (64%) previously diagnosed with skin cancer], 306 (50%) reported treatment of skin lesions with major types of non-excision therapies during follow-up: 278 (45%) cryotherapy or diathermy; 121 (20%) topical treatments. Of these 306, 150 (49%) developed SCC at double the incidence of those who did not receive these treatments, as assessed by incidence rate ratio (IRR) adjusted for age, sex, type of organ transplant, skin color and history of skin cancer at baseline, calculated by multivariable Poisson regression (IRR(adj) = 2.1, 95% confidence interval (CI) 1.4–3.1). BCC incidence was not associated with these therapies. Skin lesions in OTRs that are treated with cryotherapy, diathermy, or topical treatment warrant judicious selection and careful follow-up.
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spelling pubmed-88502142022-02-23 Destructive and topical treatments of skin lesions in organ transplant recipients and relation to skin cancer Green, Adele C. Way, Mandy Oster, Mariella Plasmeijer, Elsemieke I. Jiyad, Zainab O’Rourke, Peter Miura, Kyoko Campbell, Scott Isbel, Nicole Chambers, Daniel C. Hopkins, Peter Ferguson, Lisa E. Davis, Marcia Batista Whiteman, David C. Soyer, H. Peter Marquart, Louise Arch Dermatol Res Concise Communication Various treatments of keratotic skin lesions and early skin cancers are performed in organ transplant recipients (OTRs) at high risk of skin malignancies but the frequency of their use is unknown. We prospectively assessed the frequency of use of cryotherapy, diathermy, and topical therapies and also investigated their associations with background incidence of histologically-confirmed squamous-cell carcinoma (SCC) and basal cell carcinoma (BCC) in a cohort of OTRs in Queensland, Australia. Median follow-up ranged from 1.7 to 3.2 years across organ transplant groups. Among 285 kidney, 125 lung and 203 liver transplant recipients [382 (62%) male, 380 (62%) immunosuppressed > 5 years, 394 (64%) previously diagnosed with skin cancer], 306 (50%) reported treatment of skin lesions with major types of non-excision therapies during follow-up: 278 (45%) cryotherapy or diathermy; 121 (20%) topical treatments. Of these 306, 150 (49%) developed SCC at double the incidence of those who did not receive these treatments, as assessed by incidence rate ratio (IRR) adjusted for age, sex, type of organ transplant, skin color and history of skin cancer at baseline, calculated by multivariable Poisson regression (IRR(adj) = 2.1, 95% confidence interval (CI) 1.4–3.1). BCC incidence was not associated with these therapies. Skin lesions in OTRs that are treated with cryotherapy, diathermy, or topical treatment warrant judicious selection and careful follow-up. Springer Berlin Heidelberg 2020-09-05 2022 /pmc/articles/PMC8850214/ /pubmed/32889576 http://dx.doi.org/10.1007/s00403-020-02136-4 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Concise Communication
Green, Adele C.
Way, Mandy
Oster, Mariella
Plasmeijer, Elsemieke I.
Jiyad, Zainab
O’Rourke, Peter
Miura, Kyoko
Campbell, Scott
Isbel, Nicole
Chambers, Daniel C.
Hopkins, Peter
Ferguson, Lisa E.
Davis, Marcia Batista
Whiteman, David C.
Soyer, H. Peter
Marquart, Louise
Destructive and topical treatments of skin lesions in organ transplant recipients and relation to skin cancer
title Destructive and topical treatments of skin lesions in organ transplant recipients and relation to skin cancer
title_full Destructive and topical treatments of skin lesions in organ transplant recipients and relation to skin cancer
title_fullStr Destructive and topical treatments of skin lesions in organ transplant recipients and relation to skin cancer
title_full_unstemmed Destructive and topical treatments of skin lesions in organ transplant recipients and relation to skin cancer
title_short Destructive and topical treatments of skin lesions in organ transplant recipients and relation to skin cancer
title_sort destructive and topical treatments of skin lesions in organ transplant recipients and relation to skin cancer
topic Concise Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850214/
https://www.ncbi.nlm.nih.gov/pubmed/32889576
http://dx.doi.org/10.1007/s00403-020-02136-4
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