Role of Pyroptosis and Ferroptosis in the Progression of Atherosclerotic Plaques

Pyroptosis is a special way of programmed cell death which is dependent on the activation of cysteinyl aspartate specific proteinase 1 (Caspase-1) and Caspase-4/5/11. Ferroptosis is an iron-dependent cell death that characterized by the intra-cellular lipid peroxidation-mediated membrane damage. Pyr...

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Autores principales: Yang, Zhen, Shi, Junhe, Chen, Li, Fu, Changgeng, Shi, Dazhuo, Qu, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850398/
https://www.ncbi.nlm.nih.gov/pubmed/35186925
http://dx.doi.org/10.3389/fcell.2022.811196
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author Yang, Zhen
Shi, Junhe
Chen, Li
Fu, Changgeng
Shi, Dazhuo
Qu, Hua
author_facet Yang, Zhen
Shi, Junhe
Chen, Li
Fu, Changgeng
Shi, Dazhuo
Qu, Hua
author_sort Yang, Zhen
collection PubMed
description Pyroptosis is a special way of programmed cell death which is dependent on the activation of cysteinyl aspartate specific proteinase 1 (Caspase-1) and Caspase-4/5/11. Ferroptosis is an iron-dependent cell death that characterized by the intra-cellular lipid peroxidation-mediated membrane damage. Pyroptosis or ferroptosis in macrophages, smooth muscle cells, and vascular endothelial cells are believed to be closely related to the progression of atherosclerotic plaques. Therefore, we discuss the role of pyroptosis and ferroptosis in the development of atherosclerotic plaques and may provide new strategies for the treatment of atherosclerosis.
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spelling pubmed-88503982022-02-18 Role of Pyroptosis and Ferroptosis in the Progression of Atherosclerotic Plaques Yang, Zhen Shi, Junhe Chen, Li Fu, Changgeng Shi, Dazhuo Qu, Hua Front Cell Dev Biol Cell and Developmental Biology Pyroptosis is a special way of programmed cell death which is dependent on the activation of cysteinyl aspartate specific proteinase 1 (Caspase-1) and Caspase-4/5/11. Ferroptosis is an iron-dependent cell death that characterized by the intra-cellular lipid peroxidation-mediated membrane damage. Pyroptosis or ferroptosis in macrophages, smooth muscle cells, and vascular endothelial cells are believed to be closely related to the progression of atherosclerotic plaques. Therefore, we discuss the role of pyroptosis and ferroptosis in the development of atherosclerotic plaques and may provide new strategies for the treatment of atherosclerosis. Frontiers Media S.A. 2022-02-03 /pmc/articles/PMC8850398/ /pubmed/35186925 http://dx.doi.org/10.3389/fcell.2022.811196 Text en Copyright © 2022 Yang, Shi, Chen, Fu, Shi and Qu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Yang, Zhen
Shi, Junhe
Chen, Li
Fu, Changgeng
Shi, Dazhuo
Qu, Hua
Role of Pyroptosis and Ferroptosis in the Progression of Atherosclerotic Plaques
title Role of Pyroptosis and Ferroptosis in the Progression of Atherosclerotic Plaques
title_full Role of Pyroptosis and Ferroptosis in the Progression of Atherosclerotic Plaques
title_fullStr Role of Pyroptosis and Ferroptosis in the Progression of Atherosclerotic Plaques
title_full_unstemmed Role of Pyroptosis and Ferroptosis in the Progression of Atherosclerotic Plaques
title_short Role of Pyroptosis and Ferroptosis in the Progression of Atherosclerotic Plaques
title_sort role of pyroptosis and ferroptosis in the progression of atherosclerotic plaques
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850398/
https://www.ncbi.nlm.nih.gov/pubmed/35186925
http://dx.doi.org/10.3389/fcell.2022.811196
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