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Heparanase promotes endothelial-to-mesenchymal transition in diabetic glomerular endothelial cells through mediating ERK signaling

Glomerular endothelial cells (GEnCs) dysfunction occurs at the early stage of diabetic nephropathy (DN). One of its characteristics is endothelial-to-mesenchymal transition (EndMT). Heparanase (HPSE) is the only known mammalian endoglycosidase capable of degrading heparin sulfates and has a prominen...

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Detalles Bibliográficos
Autores principales:	Chang, Kaili, Xie, Qiyuan, Niu, Jianying, Gu, Yong, Zhao, Zhonghua, Li, Fengxia, Qin, Qiaojing, Liu, Xueguang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850459/ https://www.ncbi.nlm.nih.gov/pubmed/35173145 http://dx.doi.org/10.1038/s41420-022-00858-0

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