Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength

Mitochondrial proteolysis is an evolutionarily conserved quality-control mechanism to maintain proper mitochondrial integrity and function. However, the physiological relevance of stress-induced impaired mitochondrial protein quality remains unclear. Here, we demonstrate that LONP1, a major mitochon...

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Detalles Bibliográficos
Autores principales: Xu, Zhisheng, Fu, Tingting, Guo, Qiqi, Zhou, Danxia, Sun, Wanping, Zhou, Zheng, Chen, Xinyi, Zhang, Jingzi, Liu, Lin, Xiao, Liwei, Yin, Yujing, Jia, Yuhuan, Pang, Erkai, Chen, Yuncong, Pan, Xin, Fang, Lei, Zhu, Min-sheng, Fei, Wenyong, Lu, Bin, Gan, Zhenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850466/
https://www.ncbi.nlm.nih.gov/pubmed/35173176
http://dx.doi.org/10.1038/s41467-022-28557-5

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