Cargando…

A suspended polymeric microfluidic sensor for liquid flow rate measurement in microchannels

In this study, a microfluidic cantilever flow sensor was designed and manufactured to monitor liquid flow rate within the range of 100–1000 µl/min. System simulation was also performed to determine the influential optimal parameters and compare the results with experimental data. A flowmeter was con...

Descripción completa

Detalles Bibliográficos
Autores principales: Mohammadamini, Fatemeh, Rahbar Shahrouzi, Javad, Samadi, Mitra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850574/
https://www.ncbi.nlm.nih.gov/pubmed/35173261
http://dx.doi.org/10.1038/s41598-022-06656-z
_version_ 1784652627371360256
author Mohammadamini, Fatemeh
Rahbar Shahrouzi, Javad
Samadi, Mitra
author_facet Mohammadamini, Fatemeh
Rahbar Shahrouzi, Javad
Samadi, Mitra
author_sort Mohammadamini, Fatemeh
collection PubMed
description In this study, a microfluidic cantilever flow sensor was designed and manufactured to monitor liquid flow rate within the range of 100–1000 µl/min. System simulation was also performed to determine the influential optimal parameters and compare the results with experimental data. A flowmeter was constructed as a curved cantilever with dimensions of 6.9 × 0.5 × 0.6 mm(3) and a microchannel carved with a CO(2) laser inside the cantilever beam. The fabrication substance was Polydimethylsiloxane. Different flow rates were injected using a syringe pump to test the performance of the flowmeter. Vertical displacement of the cantilever was measured in each flowrate using a digital microscope. According to the results, the full-scale overall device accuracy was up to ± 1.39%, and the response time of the sensor was measured to be 6.3 s. The microchip sensitivity was 0.126 µm/(µl/min) in the range of measured flow rates. The sensor could also be utilized multiple times with an acceptable error value. The experimental data obtained by the constructed microchip had a linear trend (R(2) = 0.995) and were of good consistency with simulation results. Furthermore, according to the experimental and the simulation data, the initially curved cantilever structure had a higher bending and sensitivity level than a perfectly straight cantilever construction.
format Online
Article
Text
id pubmed-8850574
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-88505742022-02-17 A suspended polymeric microfluidic sensor for liquid flow rate measurement in microchannels Mohammadamini, Fatemeh Rahbar Shahrouzi, Javad Samadi, Mitra Sci Rep Article In this study, a microfluidic cantilever flow sensor was designed and manufactured to monitor liquid flow rate within the range of 100–1000 µl/min. System simulation was also performed to determine the influential optimal parameters and compare the results with experimental data. A flowmeter was constructed as a curved cantilever with dimensions of 6.9 × 0.5 × 0.6 mm(3) and a microchannel carved with a CO(2) laser inside the cantilever beam. The fabrication substance was Polydimethylsiloxane. Different flow rates were injected using a syringe pump to test the performance of the flowmeter. Vertical displacement of the cantilever was measured in each flowrate using a digital microscope. According to the results, the full-scale overall device accuracy was up to ± 1.39%, and the response time of the sensor was measured to be 6.3 s. The microchip sensitivity was 0.126 µm/(µl/min) in the range of measured flow rates. The sensor could also be utilized multiple times with an acceptable error value. The experimental data obtained by the constructed microchip had a linear trend (R(2) = 0.995) and were of good consistency with simulation results. Furthermore, according to the experimental and the simulation data, the initially curved cantilever structure had a higher bending and sensitivity level than a perfectly straight cantilever construction. Nature Publishing Group UK 2022-02-16 /pmc/articles/PMC8850574/ /pubmed/35173261 http://dx.doi.org/10.1038/s41598-022-06656-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Mohammadamini, Fatemeh
Rahbar Shahrouzi, Javad
Samadi, Mitra
A suspended polymeric microfluidic sensor for liquid flow rate measurement in microchannels
title A suspended polymeric microfluidic sensor for liquid flow rate measurement in microchannels
title_full A suspended polymeric microfluidic sensor for liquid flow rate measurement in microchannels
title_fullStr A suspended polymeric microfluidic sensor for liquid flow rate measurement in microchannels
title_full_unstemmed A suspended polymeric microfluidic sensor for liquid flow rate measurement in microchannels
title_short A suspended polymeric microfluidic sensor for liquid flow rate measurement in microchannels
title_sort suspended polymeric microfluidic sensor for liquid flow rate measurement in microchannels
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850574/
https://www.ncbi.nlm.nih.gov/pubmed/35173261
http://dx.doi.org/10.1038/s41598-022-06656-z
work_keys_str_mv AT mohammadaminifatemeh asuspendedpolymericmicrofluidicsensorforliquidflowratemeasurementinmicrochannels
AT rahbarshahrouzijavad asuspendedpolymericmicrofluidicsensorforliquidflowratemeasurementinmicrochannels
AT samadimitra asuspendedpolymericmicrofluidicsensorforliquidflowratemeasurementinmicrochannels
AT mohammadaminifatemeh suspendedpolymericmicrofluidicsensorforliquidflowratemeasurementinmicrochannels
AT rahbarshahrouzijavad suspendedpolymericmicrofluidicsensorforliquidflowratemeasurementinmicrochannels
AT samadimitra suspendedpolymericmicrofluidicsensorforliquidflowratemeasurementinmicrochannels