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A suspended polymeric microfluidic sensor for liquid flow rate measurement in microchannels
In this study, a microfluidic cantilever flow sensor was designed and manufactured to monitor liquid flow rate within the range of 100–1000 µl/min. System simulation was also performed to determine the influential optimal parameters and compare the results with experimental data. A flowmeter was con...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850574/ https://www.ncbi.nlm.nih.gov/pubmed/35173261 http://dx.doi.org/10.1038/s41598-022-06656-z |
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author | Mohammadamini, Fatemeh Rahbar Shahrouzi, Javad Samadi, Mitra |
author_facet | Mohammadamini, Fatemeh Rahbar Shahrouzi, Javad Samadi, Mitra |
author_sort | Mohammadamini, Fatemeh |
collection | PubMed |
description | In this study, a microfluidic cantilever flow sensor was designed and manufactured to monitor liquid flow rate within the range of 100–1000 µl/min. System simulation was also performed to determine the influential optimal parameters and compare the results with experimental data. A flowmeter was constructed as a curved cantilever with dimensions of 6.9 × 0.5 × 0.6 mm(3) and a microchannel carved with a CO(2) laser inside the cantilever beam. The fabrication substance was Polydimethylsiloxane. Different flow rates were injected using a syringe pump to test the performance of the flowmeter. Vertical displacement of the cantilever was measured in each flowrate using a digital microscope. According to the results, the full-scale overall device accuracy was up to ± 1.39%, and the response time of the sensor was measured to be 6.3 s. The microchip sensitivity was 0.126 µm/(µl/min) in the range of measured flow rates. The sensor could also be utilized multiple times with an acceptable error value. The experimental data obtained by the constructed microchip had a linear trend (R(2) = 0.995) and were of good consistency with simulation results. Furthermore, according to the experimental and the simulation data, the initially curved cantilever structure had a higher bending and sensitivity level than a perfectly straight cantilever construction. |
format | Online Article Text |
id | pubmed-8850574 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-88505742022-02-17 A suspended polymeric microfluidic sensor for liquid flow rate measurement in microchannels Mohammadamini, Fatemeh Rahbar Shahrouzi, Javad Samadi, Mitra Sci Rep Article In this study, a microfluidic cantilever flow sensor was designed and manufactured to monitor liquid flow rate within the range of 100–1000 µl/min. System simulation was also performed to determine the influential optimal parameters and compare the results with experimental data. A flowmeter was constructed as a curved cantilever with dimensions of 6.9 × 0.5 × 0.6 mm(3) and a microchannel carved with a CO(2) laser inside the cantilever beam. The fabrication substance was Polydimethylsiloxane. Different flow rates were injected using a syringe pump to test the performance of the flowmeter. Vertical displacement of the cantilever was measured in each flowrate using a digital microscope. According to the results, the full-scale overall device accuracy was up to ± 1.39%, and the response time of the sensor was measured to be 6.3 s. The microchip sensitivity was 0.126 µm/(µl/min) in the range of measured flow rates. The sensor could also be utilized multiple times with an acceptable error value. The experimental data obtained by the constructed microchip had a linear trend (R(2) = 0.995) and were of good consistency with simulation results. Furthermore, according to the experimental and the simulation data, the initially curved cantilever structure had a higher bending and sensitivity level than a perfectly straight cantilever construction. Nature Publishing Group UK 2022-02-16 /pmc/articles/PMC8850574/ /pubmed/35173261 http://dx.doi.org/10.1038/s41598-022-06656-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Mohammadamini, Fatemeh Rahbar Shahrouzi, Javad Samadi, Mitra A suspended polymeric microfluidic sensor for liquid flow rate measurement in microchannels |
title | A suspended polymeric microfluidic sensor for liquid flow rate measurement in microchannels |
title_full | A suspended polymeric microfluidic sensor for liquid flow rate measurement in microchannels |
title_fullStr | A suspended polymeric microfluidic sensor for liquid flow rate measurement in microchannels |
title_full_unstemmed | A suspended polymeric microfluidic sensor for liquid flow rate measurement in microchannels |
title_short | A suspended polymeric microfluidic sensor for liquid flow rate measurement in microchannels |
title_sort | suspended polymeric microfluidic sensor for liquid flow rate measurement in microchannels |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850574/ https://www.ncbi.nlm.nih.gov/pubmed/35173261 http://dx.doi.org/10.1038/s41598-022-06656-z |
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