A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis

Hexokinase 2 (HK2), which catalyzes the first committed step in glucose metabolism, is induced in cancer cells. HK2’s role in tumorigenesis has been attributed to its glucose kinase activity. Here, we describe a kinase independent HK2 activity, which contributes to metastasis. HK2 binds and sequeste...

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Detalles Bibliográficos
Autores principales: Blaha, Catherine S., Ramakrishnan, Gopalakrishnan, Jeon, Sang-Min, Nogueira, Veronique, Rho, Hyunsoo, Kang, Soeun, Bhaskar, Prashanth, Terry, Alexander R., Aissa, Alexandre F., Frolov, Maxim V., Patra, Krushna C., Brooks Robey, R., Hay, Nissim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850586/
https://www.ncbi.nlm.nih.gov/pubmed/35173161
http://dx.doi.org/10.1038/s41467-022-28440-3

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