Cargando…
Depressive symptoms reduce when dorsolateral prefrontal cortex-precuneus connectivity normalizes after functional connectivity neurofeedback
Depressive disorders contribute heavily to global disease burden; This is possibly because patients are often treated homogeneously, despite having heterogeneous symptoms with differing underlying neural mechanisms. A novel treatment that can directly influence the neural circuit relevant to an indi...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850610/ https://www.ncbi.nlm.nih.gov/pubmed/35173179 http://dx.doi.org/10.1038/s41598-022-05860-1 |
_version_ | 1784652635821834240 |
---|---|
author | Taylor, Jessica Elizabeth Yamada, Takashi Kawashima, Takahiko Kobayashi, Yuko Yoshihara, Yujiro Miyata, Jun Murai, Toshiya Kawato, Mitsuo Motegi, Tomokazu |
author_facet | Taylor, Jessica Elizabeth Yamada, Takashi Kawashima, Takahiko Kobayashi, Yuko Yoshihara, Yujiro Miyata, Jun Murai, Toshiya Kawato, Mitsuo Motegi, Tomokazu |
author_sort | Taylor, Jessica Elizabeth |
collection | PubMed |
description | Depressive disorders contribute heavily to global disease burden; This is possibly because patients are often treated homogeneously, despite having heterogeneous symptoms with differing underlying neural mechanisms. A novel treatment that can directly influence the neural circuit relevant to an individual patient’s subset of symptoms might more precisely and thus effectively aid in the alleviation of their specific symptoms. We tested this hypothesis in a proof-of-concept study using fMRI functional connectivity neurofeedback. We targeted connectivity between the left dorsolateral prefrontal cortex/middle frontal gyrus and the left precuneus/posterior cingulate cortex, because this connection has been well-established as relating to a specific subset of depressive symptoms. Specifically, this connectivity has been shown in a data-driven manner to be less anticorrelated in patients with melancholic depression than in healthy controls. Furthermore, a posterior cingulate dominant state—which results in a loss of this anticorrelation—is expected to specifically relate to an increase in rumination symptoms such as brooding. In line with predictions, we found that, with neurofeedback training, the more a participant normalized this connectivity (restored the anticorrelation), the more related (depressive and brooding symptoms), but not unrelated (trait anxiety), symptoms were reduced. Because these results look promising, this paradigm next needs to be examined with a greater sample size and with better controls. Nonetheless, here we provide preliminary evidence for a correlation between the normalization of a neural network and a reduction in related symptoms. Showing their reproducibility, these results were found in two experiments that took place several years apart by different experimenters. Indicative of its potential clinical utility, effects of this treatment remained one-two months later. Clinical trial registration: Both experiments reported here were registered clinical trials (UMIN000015249, jRCTs052180169). |
format | Online Article Text |
id | pubmed-8850610 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-88506102022-02-18 Depressive symptoms reduce when dorsolateral prefrontal cortex-precuneus connectivity normalizes after functional connectivity neurofeedback Taylor, Jessica Elizabeth Yamada, Takashi Kawashima, Takahiko Kobayashi, Yuko Yoshihara, Yujiro Miyata, Jun Murai, Toshiya Kawato, Mitsuo Motegi, Tomokazu Sci Rep Article Depressive disorders contribute heavily to global disease burden; This is possibly because patients are often treated homogeneously, despite having heterogeneous symptoms with differing underlying neural mechanisms. A novel treatment that can directly influence the neural circuit relevant to an individual patient’s subset of symptoms might more precisely and thus effectively aid in the alleviation of their specific symptoms. We tested this hypothesis in a proof-of-concept study using fMRI functional connectivity neurofeedback. We targeted connectivity between the left dorsolateral prefrontal cortex/middle frontal gyrus and the left precuneus/posterior cingulate cortex, because this connection has been well-established as relating to a specific subset of depressive symptoms. Specifically, this connectivity has been shown in a data-driven manner to be less anticorrelated in patients with melancholic depression than in healthy controls. Furthermore, a posterior cingulate dominant state—which results in a loss of this anticorrelation—is expected to specifically relate to an increase in rumination symptoms such as brooding. In line with predictions, we found that, with neurofeedback training, the more a participant normalized this connectivity (restored the anticorrelation), the more related (depressive and brooding symptoms), but not unrelated (trait anxiety), symptoms were reduced. Because these results look promising, this paradigm next needs to be examined with a greater sample size and with better controls. Nonetheless, here we provide preliminary evidence for a correlation between the normalization of a neural network and a reduction in related symptoms. Showing their reproducibility, these results were found in two experiments that took place several years apart by different experimenters. Indicative of its potential clinical utility, effects of this treatment remained one-two months later. Clinical trial registration: Both experiments reported here were registered clinical trials (UMIN000015249, jRCTs052180169). Nature Publishing Group UK 2022-02-16 /pmc/articles/PMC8850610/ /pubmed/35173179 http://dx.doi.org/10.1038/s41598-022-05860-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Taylor, Jessica Elizabeth Yamada, Takashi Kawashima, Takahiko Kobayashi, Yuko Yoshihara, Yujiro Miyata, Jun Murai, Toshiya Kawato, Mitsuo Motegi, Tomokazu Depressive symptoms reduce when dorsolateral prefrontal cortex-precuneus connectivity normalizes after functional connectivity neurofeedback |
title | Depressive symptoms reduce when dorsolateral prefrontal cortex-precuneus connectivity normalizes after functional connectivity neurofeedback |
title_full | Depressive symptoms reduce when dorsolateral prefrontal cortex-precuneus connectivity normalizes after functional connectivity neurofeedback |
title_fullStr | Depressive symptoms reduce when dorsolateral prefrontal cortex-precuneus connectivity normalizes after functional connectivity neurofeedback |
title_full_unstemmed | Depressive symptoms reduce when dorsolateral prefrontal cortex-precuneus connectivity normalizes after functional connectivity neurofeedback |
title_short | Depressive symptoms reduce when dorsolateral prefrontal cortex-precuneus connectivity normalizes after functional connectivity neurofeedback |
title_sort | depressive symptoms reduce when dorsolateral prefrontal cortex-precuneus connectivity normalizes after functional connectivity neurofeedback |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850610/ https://www.ncbi.nlm.nih.gov/pubmed/35173179 http://dx.doi.org/10.1038/s41598-022-05860-1 |
work_keys_str_mv | AT taylorjessicaelizabeth depressivesymptomsreducewhendorsolateralprefrontalcortexprecuneusconnectivitynormalizesafterfunctionalconnectivityneurofeedback AT yamadatakashi depressivesymptomsreducewhendorsolateralprefrontalcortexprecuneusconnectivitynormalizesafterfunctionalconnectivityneurofeedback AT kawashimatakahiko depressivesymptomsreducewhendorsolateralprefrontalcortexprecuneusconnectivitynormalizesafterfunctionalconnectivityneurofeedback AT kobayashiyuko depressivesymptomsreducewhendorsolateralprefrontalcortexprecuneusconnectivitynormalizesafterfunctionalconnectivityneurofeedback AT yoshiharayujiro depressivesymptomsreducewhendorsolateralprefrontalcortexprecuneusconnectivitynormalizesafterfunctionalconnectivityneurofeedback AT miyatajun depressivesymptomsreducewhendorsolateralprefrontalcortexprecuneusconnectivitynormalizesafterfunctionalconnectivityneurofeedback AT muraitoshiya depressivesymptomsreducewhendorsolateralprefrontalcortexprecuneusconnectivitynormalizesafterfunctionalconnectivityneurofeedback AT kawatomitsuo depressivesymptomsreducewhendorsolateralprefrontalcortexprecuneusconnectivitynormalizesafterfunctionalconnectivityneurofeedback AT motegitomokazu depressivesymptomsreducewhendorsolateralprefrontalcortexprecuneusconnectivitynormalizesafterfunctionalconnectivityneurofeedback |