Pseudoautosomal Region 1 Overdosage Affects the Global Transcriptome in iPSCs From Patients With Klinefelter Syndrome and High-Grade X Chromosome Aneuploidies

Klinefelter syndrome (KS) is the most prevalent aneuploidy in males and is characterized by a 47,XXY karyotype. Less frequently, higher grade sex chromosome aneuploidies (HGAs) can also occur. Here, using a paradigmatic cohort of KS and HGA induced pluripotent stem cells (iPSCs) carrying 49,XXXXY, 4...

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Detalles Bibliográficos
Autores principales: Astro, Veronica, Alowaysi, Maryam, Fiacco, Elisabetta, Saera-Vila, Alfonso, Cardona-Londoño, Kelly J., Aiese Cigliano, Riccardo, Adamo, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850648/
https://www.ncbi.nlm.nih.gov/pubmed/35186953
http://dx.doi.org/10.3389/fcell.2021.801597

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850648/
https://www.ncbi.nlm.nih.gov/pubmed/35186953
http://dx.doi.org/10.3389/fcell.2021.801597

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