Cargando…

Towards a qAOP framework for predictive toxicology - Linking data to decisions

The adverse outcome pathway (AOP) is a conceptual construct that facilitates organisation and interpretation of mechanistic data representing multiple biological levels and deriving from a range of methodological approaches including in silico, in vitro and in vivo assays. AOPs are playing an increa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paini, Alicia, Campia, Ivana, Cronin, Mark T.D., Asturiol, David, Ceriani, Lidia, Exner, Thomas E., Gao, Wang, Gomes, Caroline, Kruisselbrink, Johannes, Martens, Marvin, Meek, M.E. Bette, Pamies, David, Pletz, Julia, Scholz, Stefan, Schüttler, Andreas, Spînu, Nicoleta, Villeneuve, Daniel L., Wittwehr, Clemens, Worth, Andrew, Luijten, Mirjam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier B.V 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850654/ https://www.ncbi.nlm.nih.gov/pubmed/35211660 http://dx.doi.org/10.1016/j.comtox.2021.100195

Ejemplares similares

A matter of trust: Learning lessons about causality will make qAOPs credible
por: Spînu, Nicoleta, et al.
Publicado: (2022)

Quantitative adverse outcome pathway (qAOP) models for toxicity prediction
por: Spinu, Nicoleta, et al.
Publicado: (2020)

Probabilistic modelling of developmental neurotoxicity based on a simplified adverse outcome pathway network
por: Spînu, Nicoleta, et al.
Publicado: (2022)

The AOP-DB RDF: Applying FAIR Principles to the Semantic Integration of AOP Data Using the Research Description Framework
por: Mortensen, Holly M., et al.
Publicado: (2022)

Role of Physiologically Based Kinetic modelling in addressing environmental chemical mixtures – A review
por: Desalegn, Anteneh, et al.
Publicado: (2019)

Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations
por: Bajard, Lola, et al.
Publicado: (2023)

How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology
por: Wittwehr, Clemens, et al.
Publicado: (2017)

Building a Network of Adverse Outcome Pathways (AOPs) Incorporating the Tau-Driven AOP Toward Memory Loss (AOP429)
por: Tsamou, Maria, et al.
Publicado: (2022)

AOP Report: Uncoupling of Oxidative Phosphorylation Leading to Growth Inhibition via Decreased Cell Proliferation
por: Song, You, et al.
Publicado: (2021)

The virtual cell based assay: Current status and future perspectives
por: Graepel, Rabea, et al.
Publicado: (2017)

Water, wastewater and soil treatment by AOPs
por: Belgiorno, V.
Publicado: (2010)

Harvesting the promise of AOPs: An assessment and recommendations
por: Carusi, Annamaria, et al.
Publicado: (2018)

AOP in .NET: practical aspect-oriented programming
por: Groves, Matthew D
Publicado: (2013)

AOP report: Development of an adverse outcome pathway for oxidative DNA damage leading to mutations and chromosomal aberrations
por: Cho, Eunnara, et al.
Publicado: (2022)

Automated workflows for modelling chemical fate, kinetics and toxicity
por: Sala Benito, J.V., et al.
Publicado: (2017)

Enriching Glucoraphanin in Brassica rapa Through Replacement of BrAOP2.2/BrAOP2.3 with Non-functional Genes
por: Liu, Zhiyuan, et al.
Publicado: (2017)

AspectJ in action: enterprise AOP with Spring applications
por: Laddad, Ramnivas
Publicado: (2010)

A putative AOP for pneumonia related to COVID-19
por: Vinken, Mathieu
Publicado: (2020)

Bilateral thalamic infarction and DSA demonstrated AOP after thrombosis
por: Cao, Wenjie, et al.
Publicado: (2012)

A Comparison of the Environmental Impact of Different AOPs: Risk Indexes
por: Giménez, Jaime, et al.
Publicado: (2014)

Translating Scientific Advances in the AOP Framework to Decision Making for Nanomaterials
por: Ede, James D., et al.
Publicado: (2020)

Combined AOPs for Formaldehyde Degradation Using Heterogeneous Nanostructured Catalysts
por: Bonora, Renato, et al.
Publicado: (2020)

From Qualitative to Quantitative AOP: A Case Study of Neurodegeneration
por: Sinitsyn, Dennis, et al.
Publicado: (2022)

Beyond AOPs: A Mechanistic Evaluation of NAMs in DART Testing
por: Rajagopal, Ramya, et al.
Publicado: (2022)

A scheme to evaluate structural alerts to predict toxicity – Assessing confidence by characterising uncertainties
por: Cronin, Mark T.D., et al.
Publicado: (2022)

COVID-19 through Adverse Outcome Pathways: Building Networks to Better Understand the Disease – 3(rd) CIAO AOP Design Workshop
por: Clerbaux, Laure-Alix, et al.
Publicado: (2022)

Adverse outcome pathways: Application to enhance mechanistic understanding of neurotoxicity
por: Bal-Price, Anna, et al.
Publicado: (2017)

Similarities and Differences in RANTES- and (AOP)-RANTES–triggered Signals: Implications for Chemotaxis
por: Rodríguez-Frade, José M., et al.
Publicado: (1999)

Dihydromyricetin promotes longevity and activates the transcription factors FOXO and AOP in Drosophila
por: Fan, Xiaolan, et al.
Publicado: (2020)

sAOP: linking chemical stressors to adverse outcomes pathway networks
por: Aguayo-Orozco, Alejandro, et al.
Publicado: (2019)

Alzheimer’s Disease, and Breast and Prostate Cancer Research: Translational Failures and the Importance to Monitor Outputs and Impact of Funded Research
por: Pistollato, Francesca, et al.
Publicado: (2020)

Prediction of the Neurotoxic Potential of Chemicals Based on Modelling of Molecular Initiating Events Upstream of the Adverse Outcome Pathways of (Developmental) Neurotoxicity
por: Gadaleta, Domenico, et al.
Publicado: (2022)

An Overview of Physiologically-Based Pharmacokinetic Models for Forensic Science
por: Fairman, Kiara, et al.
Publicado: (2023)

Unlocking the potential of in silico chemical safety assessment – A report on a cross-sector symposium on current opportunities and future challenges
por: Cronin, Mark T.D., et al.
Publicado: (2019)

New version of the program "extractionchannel": Addendum to report CERN-SPS-AOP-78-20
por: Gyr, M
Publicado: (1979)

Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP)
por: Vietti, Giulia, et al.
Publicado: (2016)

AOP key event relationship report: Linking androgen receptor antagonism with nipple retention
por: Pedersen, Emilie Bak, et al.
Publicado: (2022)

Physiologically based kinetic (PBK) modelling and human biomonitoring data for mixture risk assessment
por: Pletz, Julia, et al.
Publicado: (2020)

The characterisation of AOP2: a gene associated with the biosynthesis of aliphatic alkenyl glucosinolates in Arabidopsis thaliana
por: Neal, Calida S, et al.
Publicado: (2010)

Metoprolol and Its Degradation and Transformation Products Using AOPs—Assessment of Aquatic Ecotoxicity Using QSAR
por: Voigt, Melanie, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_e8h7gkcn6e13l2hrjrelu190vn