The P300 acetyltransferase inhibitor C646 promotes membrane translocation of insulin receptor protein substrate and interaction with the insulin receptor

Inhibition of P300 acetyltransferase activity by specific inhibitor C646 has been shown to improve insulin signaling. However, the underlying molecular mechanism of this improvement remains unclear. In this study, we analyzed P300 levels of obese patients and found that they were significantly incre...

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Detalles Bibliográficos
Autores principales: Peng, Jinghua, Ramatchandirin, Balamurugan, Wang, Yu, Pearah, Alexia, Namachivayam, Kopperuncholan, Wolf, Risa M., Steele, Kimberley, MohanKumar, Krishnan, Yu, Liqing, Guo, Shaodong, White, Morris F., Maheshwari, Akhil, He, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850660/
https://www.ncbi.nlm.nih.gov/pubmed/35074429
http://dx.doi.org/10.1016/j.jbc.2022.101621

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