IL-23 production in human macrophages is regulated negatively by tumor necrosis factor α-induced protein 3 and positively by specificity protein 1 after stimulation of the toll-like receptor 7/8 signaling pathway

The IL-23/IL-17 axis plays an important role in the development of autoimmune diseases, but the mechanism regulating IL-23 production is mainly unknown. We investigated how TNFAIP3 and Sp1 affect IL-23 production by human macrophages after exposure to resiquimod, a TLR7/8 agonist. IL-23 production w...

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Detalles Bibliográficos
Autores principales: Yamaguchi, Rui, Sakamoto, Arisa, Yamaguchi, Reona, Haraguchi, Misa, Narahara, Shinji, Sugiuchi, Hiroyuki, Yamaguch, Yasuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850731/
https://www.ncbi.nlm.nih.gov/pubmed/35198762
http://dx.doi.org/10.1016/j.heliyon.2022.e08887

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