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Octahedral Pt-MOF with Au deposition for plasmonic effect and Schottky junction enhanced hydrogenothermal therapy of rheumatoid arthritis
Hydrogen (H(2)) therapy is a novel and rapidly developing strategy utilized to treat inflammatory diseases. However, the therapeutic efficacy of H(2) is largely limited with on-target off-synovium toxic effect, nonpolarity and low solubility. Herein, an intelligent H(2) nanogenerator based upon the...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850757/ https://www.ncbi.nlm.nih.gov/pubmed/35198962 http://dx.doi.org/10.1016/j.mtbio.2022.100214 |
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author | Pan, Wenzhen Li, Zheng Qiu, Shang Dai, Chengbai Wu, Shengyue Zheng, Xin Guan, Ming Gao, Fenglei |
author_facet | Pan, Wenzhen Li, Zheng Qiu, Shang Dai, Chengbai Wu, Shengyue Zheng, Xin Guan, Ming Gao, Fenglei |
author_sort | Pan, Wenzhen |
collection | PubMed |
description | Hydrogen (H(2)) therapy is a novel and rapidly developing strategy utilized to treat inflammatory diseases. However, the therapeutic efficacy of H(2) is largely limited with on-target off-synovium toxic effect, nonpolarity and low solubility. Herein, an intelligent H(2) nanogenerator based upon the metal-organic framework (MOF) loaded with polydopamine and Perovskite quantum dots is constructed for the actualization of hydrogenothermal therapy. The biodegradable polydopamine with excellent photothermal conversion efficiencies is used for photothermal therapy (PTT) of rheumatoid arthritis (RA) and perovskite quantum dots (QDs) with unique photophysical properties are used as fluorescent signals for positioning Pt-MOF@Au@QDs/PDA nanoparticles. In addition, the Pt-MOF@Au@QDs/PDA catalyzer combines Au's surface plasmon resonance excitation with Pt-MOF Schottky junction, and exhibits extremely efficient photocatalytic H(2) production under visible light irradiation. The Pt-MOF@Au@QDs/PDA achieves the aggregation of rheumatoid synovial cells by the extravasation through “ELVIS” effect (extravasation through leaky vasculature and subsequent inflammatory cell-mediated sequestration) and extremely efficient photocatalytic H(2) production. By combining PTT and H(2) therapy, the Pt-MOF@Au@QDs/PDA relieves the oxidative stress of RA, and shows significant improvement in joint damage and inhibition of the overall arthritis severity of collagen-induced RA mouse models. Therefore, the Pt-MOF@Au@QDs/PDA shows great potential in the treatment of RA and further clinical transformation. |
format | Online Article Text |
id | pubmed-8850757 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-88507572022-02-22 Octahedral Pt-MOF with Au deposition for plasmonic effect and Schottky junction enhanced hydrogenothermal therapy of rheumatoid arthritis Pan, Wenzhen Li, Zheng Qiu, Shang Dai, Chengbai Wu, Shengyue Zheng, Xin Guan, Ming Gao, Fenglei Mater Today Bio Advanced Materials for Disease Diagnosis edited by Kun Qian; Lin Huang Hydrogen (H(2)) therapy is a novel and rapidly developing strategy utilized to treat inflammatory diseases. However, the therapeutic efficacy of H(2) is largely limited with on-target off-synovium toxic effect, nonpolarity and low solubility. Herein, an intelligent H(2) nanogenerator based upon the metal-organic framework (MOF) loaded with polydopamine and Perovskite quantum dots is constructed for the actualization of hydrogenothermal therapy. The biodegradable polydopamine with excellent photothermal conversion efficiencies is used for photothermal therapy (PTT) of rheumatoid arthritis (RA) and perovskite quantum dots (QDs) with unique photophysical properties are used as fluorescent signals for positioning Pt-MOF@Au@QDs/PDA nanoparticles. In addition, the Pt-MOF@Au@QDs/PDA catalyzer combines Au's surface plasmon resonance excitation with Pt-MOF Schottky junction, and exhibits extremely efficient photocatalytic H(2) production under visible light irradiation. The Pt-MOF@Au@QDs/PDA achieves the aggregation of rheumatoid synovial cells by the extravasation through “ELVIS” effect (extravasation through leaky vasculature and subsequent inflammatory cell-mediated sequestration) and extremely efficient photocatalytic H(2) production. By combining PTT and H(2) therapy, the Pt-MOF@Au@QDs/PDA relieves the oxidative stress of RA, and shows significant improvement in joint damage and inhibition of the overall arthritis severity of collagen-induced RA mouse models. Therefore, the Pt-MOF@Au@QDs/PDA shows great potential in the treatment of RA and further clinical transformation. Elsevier 2022-02-08 /pmc/articles/PMC8850757/ /pubmed/35198962 http://dx.doi.org/10.1016/j.mtbio.2022.100214 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Advanced Materials for Disease Diagnosis edited by Kun Qian; Lin Huang Pan, Wenzhen Li, Zheng Qiu, Shang Dai, Chengbai Wu, Shengyue Zheng, Xin Guan, Ming Gao, Fenglei Octahedral Pt-MOF with Au deposition for plasmonic effect and Schottky junction enhanced hydrogenothermal therapy of rheumatoid arthritis |
title | Octahedral Pt-MOF with Au deposition for plasmonic effect and Schottky junction enhanced hydrogenothermal therapy of rheumatoid arthritis |
title_full | Octahedral Pt-MOF with Au deposition for plasmonic effect and Schottky junction enhanced hydrogenothermal therapy of rheumatoid arthritis |
title_fullStr | Octahedral Pt-MOF with Au deposition for plasmonic effect and Schottky junction enhanced hydrogenothermal therapy of rheumatoid arthritis |
title_full_unstemmed | Octahedral Pt-MOF with Au deposition for plasmonic effect and Schottky junction enhanced hydrogenothermal therapy of rheumatoid arthritis |
title_short | Octahedral Pt-MOF with Au deposition for plasmonic effect and Schottky junction enhanced hydrogenothermal therapy of rheumatoid arthritis |
title_sort | octahedral pt-mof with au deposition for plasmonic effect and schottky junction enhanced hydrogenothermal therapy of rheumatoid arthritis |
topic | Advanced Materials for Disease Diagnosis edited by Kun Qian; Lin Huang |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850757/ https://www.ncbi.nlm.nih.gov/pubmed/35198962 http://dx.doi.org/10.1016/j.mtbio.2022.100214 |
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