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Single-Cell Sequencing Facilitates Elucidation of HIV Immunopathogenesis: A Review of Current Literature

Knowledge gaps remain in the understanding of HIV disease establishment and progression. Scientists continue to strive in their endeavor to elucidate the precise underlying immunopathogenic mechanisms of HIV-related disease, in order to identify possible preventive and therapeutic targets. A useful...

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Autores principales: Zaongo, Silvere D., Harypursat, Vijay, Chen, Yaokai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850777/
https://www.ncbi.nlm.nih.gov/pubmed/35185920
http://dx.doi.org/10.3389/fimmu.2022.828860
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author Zaongo, Silvere D.
Harypursat, Vijay
Chen, Yaokai
author_facet Zaongo, Silvere D.
Harypursat, Vijay
Chen, Yaokai
author_sort Zaongo, Silvere D.
collection PubMed
description Knowledge gaps remain in the understanding of HIV disease establishment and progression. Scientists continue to strive in their endeavor to elucidate the precise underlying immunopathogenic mechanisms of HIV-related disease, in order to identify possible preventive and therapeutic targets. A useful tool in the quest to reveal some of the enigmas related to HIV infection and disease is the single-cell sequencing (scRNA-seq) technique. With its proven capacity to elucidate critical processes in cell formation and differentiation, to decipher critical hematopoietic pathways, and to understand the regulatory gene networks that predict immune function, scRNA-seq is further considered to be a potentially useful tool to explore HIV immunopathogenesis. In this article, we provide an overview of single-cell sequencing platforms, before delving into research findings gleaned from the use of single cell sequencing in HIV research, as published in recent literature. Finally, we describe two important avenues of research that we believe should be further investigated using the single-cell sequencing technique.
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spelling pubmed-88507772022-02-18 Single-Cell Sequencing Facilitates Elucidation of HIV Immunopathogenesis: A Review of Current Literature Zaongo, Silvere D. Harypursat, Vijay Chen, Yaokai Front Immunol Immunology Knowledge gaps remain in the understanding of HIV disease establishment and progression. Scientists continue to strive in their endeavor to elucidate the precise underlying immunopathogenic mechanisms of HIV-related disease, in order to identify possible preventive and therapeutic targets. A useful tool in the quest to reveal some of the enigmas related to HIV infection and disease is the single-cell sequencing (scRNA-seq) technique. With its proven capacity to elucidate critical processes in cell formation and differentiation, to decipher critical hematopoietic pathways, and to understand the regulatory gene networks that predict immune function, scRNA-seq is further considered to be a potentially useful tool to explore HIV immunopathogenesis. In this article, we provide an overview of single-cell sequencing platforms, before delving into research findings gleaned from the use of single cell sequencing in HIV research, as published in recent literature. Finally, we describe two important avenues of research that we believe should be further investigated using the single-cell sequencing technique. Frontiers Media S.A. 2022-02-03 /pmc/articles/PMC8850777/ /pubmed/35185920 http://dx.doi.org/10.3389/fimmu.2022.828860 Text en Copyright © 2022 Zaongo, Harypursat and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zaongo, Silvere D.
Harypursat, Vijay
Chen, Yaokai
Single-Cell Sequencing Facilitates Elucidation of HIV Immunopathogenesis: A Review of Current Literature
title Single-Cell Sequencing Facilitates Elucidation of HIV Immunopathogenesis: A Review of Current Literature
title_full Single-Cell Sequencing Facilitates Elucidation of HIV Immunopathogenesis: A Review of Current Literature
title_fullStr Single-Cell Sequencing Facilitates Elucidation of HIV Immunopathogenesis: A Review of Current Literature
title_full_unstemmed Single-Cell Sequencing Facilitates Elucidation of HIV Immunopathogenesis: A Review of Current Literature
title_short Single-Cell Sequencing Facilitates Elucidation of HIV Immunopathogenesis: A Review of Current Literature
title_sort single-cell sequencing facilitates elucidation of hiv immunopathogenesis: a review of current literature
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850777/
https://www.ncbi.nlm.nih.gov/pubmed/35185920
http://dx.doi.org/10.3389/fimmu.2022.828860
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