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Single-Cell Sequencing Facilitates Elucidation of HIV Immunopathogenesis: A Review of Current Literature
Knowledge gaps remain in the understanding of HIV disease establishment and progression. Scientists continue to strive in their endeavor to elucidate the precise underlying immunopathogenic mechanisms of HIV-related disease, in order to identify possible preventive and therapeutic targets. A useful...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850777/ https://www.ncbi.nlm.nih.gov/pubmed/35185920 http://dx.doi.org/10.3389/fimmu.2022.828860 |
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author | Zaongo, Silvere D. Harypursat, Vijay Chen, Yaokai |
author_facet | Zaongo, Silvere D. Harypursat, Vijay Chen, Yaokai |
author_sort | Zaongo, Silvere D. |
collection | PubMed |
description | Knowledge gaps remain in the understanding of HIV disease establishment and progression. Scientists continue to strive in their endeavor to elucidate the precise underlying immunopathogenic mechanisms of HIV-related disease, in order to identify possible preventive and therapeutic targets. A useful tool in the quest to reveal some of the enigmas related to HIV infection and disease is the single-cell sequencing (scRNA-seq) technique. With its proven capacity to elucidate critical processes in cell formation and differentiation, to decipher critical hematopoietic pathways, and to understand the regulatory gene networks that predict immune function, scRNA-seq is further considered to be a potentially useful tool to explore HIV immunopathogenesis. In this article, we provide an overview of single-cell sequencing platforms, before delving into research findings gleaned from the use of single cell sequencing in HIV research, as published in recent literature. Finally, we describe two important avenues of research that we believe should be further investigated using the single-cell sequencing technique. |
format | Online Article Text |
id | pubmed-8850777 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88507772022-02-18 Single-Cell Sequencing Facilitates Elucidation of HIV Immunopathogenesis: A Review of Current Literature Zaongo, Silvere D. Harypursat, Vijay Chen, Yaokai Front Immunol Immunology Knowledge gaps remain in the understanding of HIV disease establishment and progression. Scientists continue to strive in their endeavor to elucidate the precise underlying immunopathogenic mechanisms of HIV-related disease, in order to identify possible preventive and therapeutic targets. A useful tool in the quest to reveal some of the enigmas related to HIV infection and disease is the single-cell sequencing (scRNA-seq) technique. With its proven capacity to elucidate critical processes in cell formation and differentiation, to decipher critical hematopoietic pathways, and to understand the regulatory gene networks that predict immune function, scRNA-seq is further considered to be a potentially useful tool to explore HIV immunopathogenesis. In this article, we provide an overview of single-cell sequencing platforms, before delving into research findings gleaned from the use of single cell sequencing in HIV research, as published in recent literature. Finally, we describe two important avenues of research that we believe should be further investigated using the single-cell sequencing technique. Frontiers Media S.A. 2022-02-03 /pmc/articles/PMC8850777/ /pubmed/35185920 http://dx.doi.org/10.3389/fimmu.2022.828860 Text en Copyright © 2022 Zaongo, Harypursat and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Zaongo, Silvere D. Harypursat, Vijay Chen, Yaokai Single-Cell Sequencing Facilitates Elucidation of HIV Immunopathogenesis: A Review of Current Literature |
title | Single-Cell Sequencing Facilitates Elucidation of HIV Immunopathogenesis: A Review of Current Literature |
title_full | Single-Cell Sequencing Facilitates Elucidation of HIV Immunopathogenesis: A Review of Current Literature |
title_fullStr | Single-Cell Sequencing Facilitates Elucidation of HIV Immunopathogenesis: A Review of Current Literature |
title_full_unstemmed | Single-Cell Sequencing Facilitates Elucidation of HIV Immunopathogenesis: A Review of Current Literature |
title_short | Single-Cell Sequencing Facilitates Elucidation of HIV Immunopathogenesis: A Review of Current Literature |
title_sort | single-cell sequencing facilitates elucidation of hiv immunopathogenesis: a review of current literature |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850777/ https://www.ncbi.nlm.nih.gov/pubmed/35185920 http://dx.doi.org/10.3389/fimmu.2022.828860 |
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