Cargando…
Value of Contrast-Enhanced Ultrasound for Evaluation of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma
The aim of the study was to evaluate the diagnostic value of contrast-enhanced ultrasound (CEUS) in distinguishing between benign and malignant cervical lymph nodes (LNs) in patients with papillary thyroid carcinoma (PTC). Two hundred and one cervical LNs (157 metastatic from PTC and 44 benign) were...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850786/ https://www.ncbi.nlm.nih.gov/pubmed/35185795 http://dx.doi.org/10.3389/fendo.2022.812475 |
_version_ | 1784652675126657024 |
---|---|
author | Fang, Fengkai Gong, Yi Liao, Liyan Ye, Fei Zuo, Zhongkun Li, Xiaodu Zhang, Qi Tang, Kui Xu, Yan Zhang, Rongsen Chen, Sijie Niu, Chengcheng |
author_facet | Fang, Fengkai Gong, Yi Liao, Liyan Ye, Fei Zuo, Zhongkun Li, Xiaodu Zhang, Qi Tang, Kui Xu, Yan Zhang, Rongsen Chen, Sijie Niu, Chengcheng |
author_sort | Fang, Fengkai |
collection | PubMed |
description | The aim of the study was to evaluate the diagnostic value of contrast-enhanced ultrasound (CEUS) in distinguishing between benign and malignant cervical lymph nodes (LNs) in patients with papillary thyroid carcinoma (PTC). Two hundred and one cervical LNs (157 metastatic from PTC and 44 benign) were evaluated using conventional ultrasonography (US) and CEUS before biopsy or surgery. Histopathology was used as the gold standard. We evaluated the size, long axis/short axis ratio (L/S), fatty hilum, hyper-echogenicity, calcification, cystic change, peripheral vascularity and CEUS parameters for each lymph nodule. The CEUS parameters included enhancement type, homogeneity, perfusion type, ring enhancement, peak intensity (PI) index and area under the curve (AUC) index. Univariate analysis demonstrated that compared with benign LNs, malignant LNs more frequently had L/S < 2, absence of a fatty hilum, presence of hyper-echogenicity, presence of calcification, peripheral vascularity, hyper-enhancement, heterogeneous enhancement, centripetal perfusion, ring enhancement, PI index > 1 and AUC index > 1 on preoperative US and CEUS. Binary logistic regression analysis demonstrated that hyper-enhancement, centripetal perfusion, and ring enhancement are independent CEUS characteristics related to malignant LNs for their differentiation from benign LNs (all p < 0.05). Our study indicated that preoperative CEUS characteristics may serve as a useful tool to identify malignant cervical LNs from benign cervical LNs. |
format | Online Article Text |
id | pubmed-8850786 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88507862022-02-18 Value of Contrast-Enhanced Ultrasound for Evaluation of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma Fang, Fengkai Gong, Yi Liao, Liyan Ye, Fei Zuo, Zhongkun Li, Xiaodu Zhang, Qi Tang, Kui Xu, Yan Zhang, Rongsen Chen, Sijie Niu, Chengcheng Front Endocrinol (Lausanne) Endocrinology The aim of the study was to evaluate the diagnostic value of contrast-enhanced ultrasound (CEUS) in distinguishing between benign and malignant cervical lymph nodes (LNs) in patients with papillary thyroid carcinoma (PTC). Two hundred and one cervical LNs (157 metastatic from PTC and 44 benign) were evaluated using conventional ultrasonography (US) and CEUS before biopsy or surgery. Histopathology was used as the gold standard. We evaluated the size, long axis/short axis ratio (L/S), fatty hilum, hyper-echogenicity, calcification, cystic change, peripheral vascularity and CEUS parameters for each lymph nodule. The CEUS parameters included enhancement type, homogeneity, perfusion type, ring enhancement, peak intensity (PI) index and area under the curve (AUC) index. Univariate analysis demonstrated that compared with benign LNs, malignant LNs more frequently had L/S < 2, absence of a fatty hilum, presence of hyper-echogenicity, presence of calcification, peripheral vascularity, hyper-enhancement, heterogeneous enhancement, centripetal perfusion, ring enhancement, PI index > 1 and AUC index > 1 on preoperative US and CEUS. Binary logistic regression analysis demonstrated that hyper-enhancement, centripetal perfusion, and ring enhancement are independent CEUS characteristics related to malignant LNs for their differentiation from benign LNs (all p < 0.05). Our study indicated that preoperative CEUS characteristics may serve as a useful tool to identify malignant cervical LNs from benign cervical LNs. Frontiers Media S.A. 2022-02-03 /pmc/articles/PMC8850786/ /pubmed/35185795 http://dx.doi.org/10.3389/fendo.2022.812475 Text en Copyright © 2022 Fang, Gong, Liao, Ye, Zuo, Li, Zhang, Tang, Xu, Zhang, Chen and Niu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Fang, Fengkai Gong, Yi Liao, Liyan Ye, Fei Zuo, Zhongkun Li, Xiaodu Zhang, Qi Tang, Kui Xu, Yan Zhang, Rongsen Chen, Sijie Niu, Chengcheng Value of Contrast-Enhanced Ultrasound for Evaluation of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma |
title | Value of Contrast-Enhanced Ultrasound for Evaluation of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma |
title_full | Value of Contrast-Enhanced Ultrasound for Evaluation of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma |
title_fullStr | Value of Contrast-Enhanced Ultrasound for Evaluation of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma |
title_full_unstemmed | Value of Contrast-Enhanced Ultrasound for Evaluation of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma |
title_short | Value of Contrast-Enhanced Ultrasound for Evaluation of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma |
title_sort | value of contrast-enhanced ultrasound for evaluation of cervical lymph node metastasis in papillary thyroid carcinoma |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850786/ https://www.ncbi.nlm.nih.gov/pubmed/35185795 http://dx.doi.org/10.3389/fendo.2022.812475 |
work_keys_str_mv | AT fangfengkai valueofcontrastenhancedultrasoundforevaluationofcervicallymphnodemetastasisinpapillarythyroidcarcinoma AT gongyi valueofcontrastenhancedultrasoundforevaluationofcervicallymphnodemetastasisinpapillarythyroidcarcinoma AT liaoliyan valueofcontrastenhancedultrasoundforevaluationofcervicallymphnodemetastasisinpapillarythyroidcarcinoma AT yefei valueofcontrastenhancedultrasoundforevaluationofcervicallymphnodemetastasisinpapillarythyroidcarcinoma AT zuozhongkun valueofcontrastenhancedultrasoundforevaluationofcervicallymphnodemetastasisinpapillarythyroidcarcinoma AT lixiaodu valueofcontrastenhancedultrasoundforevaluationofcervicallymphnodemetastasisinpapillarythyroidcarcinoma AT zhangqi valueofcontrastenhancedultrasoundforevaluationofcervicallymphnodemetastasisinpapillarythyroidcarcinoma AT tangkui valueofcontrastenhancedultrasoundforevaluationofcervicallymphnodemetastasisinpapillarythyroidcarcinoma AT xuyan valueofcontrastenhancedultrasoundforevaluationofcervicallymphnodemetastasisinpapillarythyroidcarcinoma AT zhangrongsen valueofcontrastenhancedultrasoundforevaluationofcervicallymphnodemetastasisinpapillarythyroidcarcinoma AT chensijie valueofcontrastenhancedultrasoundforevaluationofcervicallymphnodemetastasisinpapillarythyroidcarcinoma AT niuchengcheng valueofcontrastenhancedultrasoundforevaluationofcervicallymphnodemetastasisinpapillarythyroidcarcinoma |