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Deletion of RNF186 expression suppresses diet-induced hepatic steatosis by regulating insulin activity

RING finger protein186 (RNF186) is dramatically upregulated in steatotic livers. The physiological role of RNF186 in non-alcoholic fatty liver disease (NAFLD) remains obscure. Here, we found that hepatocyte-specific RNF186 knockout (RNF186(LKO)) mice were protected from HFD-induced obesity. RNF186 a...

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Detalles Bibliográficos
Autores principales:	Hu, Xiuqi, Zhang, Qifan, Guo, Manyu, Yuan, Qianqian, Tong, Xin, Zhang, Qing, Lin, Li, Zhang, Lei, Lv, Shujuan, Liu, Xiaojun, Gao, Chaobing, Chang, Yongsheng, Zhang, Huabing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850801/ https://www.ncbi.nlm.nih.gov/pubmed/35198905 http://dx.doi.org/10.1016/j.isci.2022.103859

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