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Peripapillary Capillary Network in Methanol Induced Optic Neuropathy
PURPOSE: To present the optical coherence tomography angiography (OCT-A) findings of the radial peripapillary capillary (RPC) network in an individual with severe bilateral methanol-induced toxic optic neuropathy (MTON) in comparison to a normal subject and a patient with retinitis pigmentosa. CASE...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PUBLISHED BY KNOWLEDGE E
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850859/ https://www.ncbi.nlm.nih.gov/pubmed/35194505 http://dx.doi.org/10.18502/jovr.v17i1.10180 |
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author | Hassanpour, Kiana Mohammadi, Negin Sabbaghi, Hamideh Amirabadi, Alireza Pakravan, Mohammad |
author_facet | Hassanpour, Kiana Mohammadi, Negin Sabbaghi, Hamideh Amirabadi, Alireza Pakravan, Mohammad |
author_sort | Hassanpour, Kiana |
collection | PubMed |
description | PURPOSE: To present the optical coherence tomography angiography (OCT-A) findings of the radial peripapillary capillary (RPC) network in an individual with severe bilateral methanol-induced toxic optic neuropathy (MTON) in comparison to a normal subject and a patient with retinitis pigmentosa. CASE REPORT: A 35-year-old man with severe bilateral MTON was referred to the neuro-ophthalmology clinic at the Labbafinejad Medical Center. The Angio Vue OCT 3D set of 4.5 [Formula: see text] 4.5 mm was used to measure the disc and peripapillary vessel density. Two subjects were examined with the same protocol as controls to determine the effect on the RPC vessel density in multiple scenarios. One of the controls was a healthy individual with the prerequisite matches of age and sex while the second one was a known retinitis pigmentosa (RP) patient. RPC density was measured as 37.7 in the patient with MTON, 46.9 in the RP patient, and 54.7 in the healthy control. CONCLUSION: The reduction in the RPC vessel density in a patient with MTON compared to that of a healthy individual and also a patient with RP may be due to the loss of capillaries secondary to the loss of nerve fibers and ganglion cells. Moreover, MTON can be considered an optic neuropathy with direct mitochondrial damage to the endothelial cells of the capillaries. |
format | Online Article Text |
id | pubmed-8850859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | PUBLISHED BY KNOWLEDGE E |
record_format | MEDLINE/PubMed |
spelling | pubmed-88508592022-02-21 Peripapillary Capillary Network in Methanol Induced Optic Neuropathy Hassanpour, Kiana Mohammadi, Negin Sabbaghi, Hamideh Amirabadi, Alireza Pakravan, Mohammad J Ophthalmic Vis Res Case Report PURPOSE: To present the optical coherence tomography angiography (OCT-A) findings of the radial peripapillary capillary (RPC) network in an individual with severe bilateral methanol-induced toxic optic neuropathy (MTON) in comparison to a normal subject and a patient with retinitis pigmentosa. CASE REPORT: A 35-year-old man with severe bilateral MTON was referred to the neuro-ophthalmology clinic at the Labbafinejad Medical Center. The Angio Vue OCT 3D set of 4.5 [Formula: see text] 4.5 mm was used to measure the disc and peripapillary vessel density. Two subjects were examined with the same protocol as controls to determine the effect on the RPC vessel density in multiple scenarios. One of the controls was a healthy individual with the prerequisite matches of age and sex while the second one was a known retinitis pigmentosa (RP) patient. RPC density was measured as 37.7 in the patient with MTON, 46.9 in the RP patient, and 54.7 in the healthy control. CONCLUSION: The reduction in the RPC vessel density in a patient with MTON compared to that of a healthy individual and also a patient with RP may be due to the loss of capillaries secondary to the loss of nerve fibers and ganglion cells. Moreover, MTON can be considered an optic neuropathy with direct mitochondrial damage to the endothelial cells of the capillaries. PUBLISHED BY KNOWLEDGE E 2022-01-21 /pmc/articles/PMC8850859/ /pubmed/35194505 http://dx.doi.org/10.18502/jovr.v17i1.10180 Text en Copyright © 2022 Hassanpour et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Hassanpour, Kiana Mohammadi, Negin Sabbaghi, Hamideh Amirabadi, Alireza Pakravan, Mohammad Peripapillary Capillary Network in Methanol Induced Optic Neuropathy |
title | Peripapillary Capillary Network in Methanol Induced Optic Neuropathy |
title_full | Peripapillary Capillary Network in Methanol Induced Optic Neuropathy |
title_fullStr | Peripapillary Capillary Network in Methanol Induced Optic Neuropathy |
title_full_unstemmed | Peripapillary Capillary Network in Methanol Induced Optic Neuropathy |
title_short | Peripapillary Capillary Network in Methanol Induced Optic Neuropathy |
title_sort | peripapillary capillary network in methanol induced optic neuropathy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850859/ https://www.ncbi.nlm.nih.gov/pubmed/35194505 http://dx.doi.org/10.18502/jovr.v17i1.10180 |
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