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Proanthocyanidins Inhibit the Transmission of Spinal Pain Information Through a Presynaptic Mechanism in a Mouse Inflammatory Pain Model

Inflammatory pain is one of the most common symptoms of clinical pain that seriously affects patient quality of life, but it currently has limited therapeutic options. Proanthocyanidins, a group of polyphenols enriched in plants and foods, have been reported to exert anti-inflammatory pain-alleviati...

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Autores principales: Fan, Hongwei, Wu, Zhenyu, Zhu, DaYu, Gu, Junxiang, Xu, Mang, Zhang, Mingzhe, Duan, Haokai, Li, Yunqing, Chen, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850919/
https://www.ncbi.nlm.nih.gov/pubmed/35185451
http://dx.doi.org/10.3389/fnins.2021.804722
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author Fan, Hongwei
Wu, Zhenyu
Zhu, DaYu
Gu, Junxiang
Xu, Mang
Zhang, Mingzhe
Duan, Haokai
Li, Yunqing
Chen, Tao
author_facet Fan, Hongwei
Wu, Zhenyu
Zhu, DaYu
Gu, Junxiang
Xu, Mang
Zhang, Mingzhe
Duan, Haokai
Li, Yunqing
Chen, Tao
author_sort Fan, Hongwei
collection PubMed
description Inflammatory pain is one of the most common symptoms of clinical pain that seriously affects patient quality of life, but it currently has limited therapeutic options. Proanthocyanidins, a group of polyphenols enriched in plants and foods, have been reported to exert anti-inflammatory pain-alleviating effects. However, the mechanism by which proanthocyanidins relieve inflammatory pain in the central nervous system is unclear. In the present study, we observed that intrathecal injection of proanthocyanidins inhibited mechanical and thermal pain sensitivity in mice with inflammatory pain induced by Complete Freund’s Adjuvant (CFA) injection. Electrophysiological results further showed that proanthocyanidins inhibited the frequency of spontaneous excitatory postsynaptic currents without affecting the spontaneous inhibitory postsynaptic currents or the intrinsic properties of parabrachial nucleus-projecting neurons in the spinal cord. The effect of proanthocyanidins may be mediated by their inhibition of phosphorylated activation of the PI3K/Akt/mTOR pathway molecules in dorsal root ganglia neurons. In summary, intrathecal injection of procyanidin induces an obvious anti-inflammatory pain effect in mice by inhibiting peripheral excitatory inputs to spinal neurons that send nociceptive information to supraspinal areas.
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spelling pubmed-88509192022-02-18 Proanthocyanidins Inhibit the Transmission of Spinal Pain Information Through a Presynaptic Mechanism in a Mouse Inflammatory Pain Model Fan, Hongwei Wu, Zhenyu Zhu, DaYu Gu, Junxiang Xu, Mang Zhang, Mingzhe Duan, Haokai Li, Yunqing Chen, Tao Front Neurosci Neuroscience Inflammatory pain is one of the most common symptoms of clinical pain that seriously affects patient quality of life, but it currently has limited therapeutic options. Proanthocyanidins, a group of polyphenols enriched in plants and foods, have been reported to exert anti-inflammatory pain-alleviating effects. However, the mechanism by which proanthocyanidins relieve inflammatory pain in the central nervous system is unclear. In the present study, we observed that intrathecal injection of proanthocyanidins inhibited mechanical and thermal pain sensitivity in mice with inflammatory pain induced by Complete Freund’s Adjuvant (CFA) injection. Electrophysiological results further showed that proanthocyanidins inhibited the frequency of spontaneous excitatory postsynaptic currents without affecting the spontaneous inhibitory postsynaptic currents or the intrinsic properties of parabrachial nucleus-projecting neurons in the spinal cord. The effect of proanthocyanidins may be mediated by their inhibition of phosphorylated activation of the PI3K/Akt/mTOR pathway molecules in dorsal root ganglia neurons. In summary, intrathecal injection of procyanidin induces an obvious anti-inflammatory pain effect in mice by inhibiting peripheral excitatory inputs to spinal neurons that send nociceptive information to supraspinal areas. Frontiers Media S.A. 2022-02-03 /pmc/articles/PMC8850919/ /pubmed/35185451 http://dx.doi.org/10.3389/fnins.2021.804722 Text en Copyright © 2022 Fan, Wu, Zhu, Gu, Xu, Zhang, Duan, Li and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Fan, Hongwei
Wu, Zhenyu
Zhu, DaYu
Gu, Junxiang
Xu, Mang
Zhang, Mingzhe
Duan, Haokai
Li, Yunqing
Chen, Tao
Proanthocyanidins Inhibit the Transmission of Spinal Pain Information Through a Presynaptic Mechanism in a Mouse Inflammatory Pain Model
title Proanthocyanidins Inhibit the Transmission of Spinal Pain Information Through a Presynaptic Mechanism in a Mouse Inflammatory Pain Model
title_full Proanthocyanidins Inhibit the Transmission of Spinal Pain Information Through a Presynaptic Mechanism in a Mouse Inflammatory Pain Model
title_fullStr Proanthocyanidins Inhibit the Transmission of Spinal Pain Information Through a Presynaptic Mechanism in a Mouse Inflammatory Pain Model
title_full_unstemmed Proanthocyanidins Inhibit the Transmission of Spinal Pain Information Through a Presynaptic Mechanism in a Mouse Inflammatory Pain Model
title_short Proanthocyanidins Inhibit the Transmission of Spinal Pain Information Through a Presynaptic Mechanism in a Mouse Inflammatory Pain Model
title_sort proanthocyanidins inhibit the transmission of spinal pain information through a presynaptic mechanism in a mouse inflammatory pain model
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850919/
https://www.ncbi.nlm.nih.gov/pubmed/35185451
http://dx.doi.org/10.3389/fnins.2021.804722
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