Disruption of KCC2 in Parvalbumin-Positive Interneurons Is Associated With a Decreased Seizure Threshold and a Progressive Loss of Parvalbumin-Positive Interneurons

GABA(A) receptors are ligand-gated ion channels, which are predominantly permeable for chloride. The neuronal K-Cl cotransporter KCC2 lowers the intraneuronal chloride concentration and thus plays an important role for GABA signaling. KCC2 loss-of-function is associated with seizures and epilepsy. H...

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Detalles Bibliográficos
Autores principales: Herrmann, Tanja, Gerth, Melanie, Dittmann, Ralf, Pensold, Daniel, Ungelenk, Martin, Liebmann, Lutz, Hübner, Christian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850922/
https://www.ncbi.nlm.nih.gov/pubmed/35185464
http://dx.doi.org/10.3389/fnmol.2021.807090

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