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Association Between Lipid Accumulation Product and Cognitive Function in Hypertensive Patients With Normal Weight: Insight From the China H-type Hypertension Registry Study
BACKGROUND: Hypertension is a major cardiovascular risk factor for cognitive impairment. Lipid accumulation product (LAP), an index that represents fat overaccumulation in the body, has been shown to be associated with cardiovascular disease. Nevertheless, the relationship between LAP and cognitive...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851034/ https://www.ncbi.nlm.nih.gov/pubmed/35185745 http://dx.doi.org/10.3389/fneur.2021.732757 |
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author | Xie, Yanyou Li, Junpei Yu, Guotao Zhou, Xinlei Zhou, Wei Zhu, Lingjuan Wang, Tao Huang, Xiao Bao, Huihui Cheng, Xiaoshu |
author_facet | Xie, Yanyou Li, Junpei Yu, Guotao Zhou, Xinlei Zhou, Wei Zhu, Lingjuan Wang, Tao Huang, Xiao Bao, Huihui Cheng, Xiaoshu |
author_sort | Xie, Yanyou |
collection | PubMed |
description | BACKGROUND: Hypertension is a major cardiovascular risk factor for cognitive impairment. Lipid accumulation product (LAP), an index that represents fat overaccumulation in the body, has been shown to be associated with cardiovascular disease. Nevertheless, the relationship between LAP and cognitive function in hypertensive patients with normal weight has been infrequently studied. OBJECTIVE: This study aimed to assess the relationship between LAP and cognitive function in hypertensive patients with normal weight. METHODS: This study included 5,542 Chinese hypertensive patients with normal weight. Cognitive function was evaluated using the Mini-Mental State Examination (MMSE). The relationship between LAP and MMSE scores was evaluated using multiple linear regression. RESULTS: The mean age of the participants was 64.8 ± 9.3 years, and 2,700 were men (48.7%). The mean MMSE score was 24.5 ± 5.1 in men and 19.2 ± 6.5 in women. The mean LAP was 26.2 ± 25.5 in men and 42.5 ± 34 in women. Log(10)-LAP showed a significant positive association with MMSE score (men: β = 0.69, 95% CI 0.14–1.24, p = 0.015; women: β = 1.03, 95% CI 0.16–1.90, p = 0.020). When LAP was divided into 3 groups according to tertiles, participants in the third LAP tertile had higher MMSE scores for both men (p for trend = 0.04) and women (p for trend = 0.015). CONCLUSION: LAP showed an independent positive association with MMSE in Chinese hypertensive patients with normal weight. |
format | Online Article Text |
id | pubmed-8851034 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88510342022-02-18 Association Between Lipid Accumulation Product and Cognitive Function in Hypertensive Patients With Normal Weight: Insight From the China H-type Hypertension Registry Study Xie, Yanyou Li, Junpei Yu, Guotao Zhou, Xinlei Zhou, Wei Zhu, Lingjuan Wang, Tao Huang, Xiao Bao, Huihui Cheng, Xiaoshu Front Neurol Neurology BACKGROUND: Hypertension is a major cardiovascular risk factor for cognitive impairment. Lipid accumulation product (LAP), an index that represents fat overaccumulation in the body, has been shown to be associated with cardiovascular disease. Nevertheless, the relationship between LAP and cognitive function in hypertensive patients with normal weight has been infrequently studied. OBJECTIVE: This study aimed to assess the relationship between LAP and cognitive function in hypertensive patients with normal weight. METHODS: This study included 5,542 Chinese hypertensive patients with normal weight. Cognitive function was evaluated using the Mini-Mental State Examination (MMSE). The relationship between LAP and MMSE scores was evaluated using multiple linear regression. RESULTS: The mean age of the participants was 64.8 ± 9.3 years, and 2,700 were men (48.7%). The mean MMSE score was 24.5 ± 5.1 in men and 19.2 ± 6.5 in women. The mean LAP was 26.2 ± 25.5 in men and 42.5 ± 34 in women. Log(10)-LAP showed a significant positive association with MMSE score (men: β = 0.69, 95% CI 0.14–1.24, p = 0.015; women: β = 1.03, 95% CI 0.16–1.90, p = 0.020). When LAP was divided into 3 groups according to tertiles, participants in the third LAP tertile had higher MMSE scores for both men (p for trend = 0.04) and women (p for trend = 0.015). CONCLUSION: LAP showed an independent positive association with MMSE in Chinese hypertensive patients with normal weight. Frontiers Media S.A. 2022-02-03 /pmc/articles/PMC8851034/ /pubmed/35185745 http://dx.doi.org/10.3389/fneur.2021.732757 Text en Copyright © 2022 Xie, Li, Yu, Zhou, Zhou, Zhu, Wang, Huang, Bao and Cheng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Xie, Yanyou Li, Junpei Yu, Guotao Zhou, Xinlei Zhou, Wei Zhu, Lingjuan Wang, Tao Huang, Xiao Bao, Huihui Cheng, Xiaoshu Association Between Lipid Accumulation Product and Cognitive Function in Hypertensive Patients With Normal Weight: Insight From the China H-type Hypertension Registry Study |
title | Association Between Lipid Accumulation Product and Cognitive Function in Hypertensive Patients With Normal Weight: Insight From the China H-type Hypertension Registry Study |
title_full | Association Between Lipid Accumulation Product and Cognitive Function in Hypertensive Patients With Normal Weight: Insight From the China H-type Hypertension Registry Study |
title_fullStr | Association Between Lipid Accumulation Product and Cognitive Function in Hypertensive Patients With Normal Weight: Insight From the China H-type Hypertension Registry Study |
title_full_unstemmed | Association Between Lipid Accumulation Product and Cognitive Function in Hypertensive Patients With Normal Weight: Insight From the China H-type Hypertension Registry Study |
title_short | Association Between Lipid Accumulation Product and Cognitive Function in Hypertensive Patients With Normal Weight: Insight From the China H-type Hypertension Registry Study |
title_sort | association between lipid accumulation product and cognitive function in hypertensive patients with normal weight: insight from the china h-type hypertension registry study |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851034/ https://www.ncbi.nlm.nih.gov/pubmed/35185745 http://dx.doi.org/10.3389/fneur.2021.732757 |
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