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Association Between Lipid Accumulation Product and Cognitive Function in Hypertensive Patients With Normal Weight: Insight From the China H-type Hypertension Registry Study

BACKGROUND: Hypertension is a major cardiovascular risk factor for cognitive impairment. Lipid accumulation product (LAP), an index that represents fat overaccumulation in the body, has been shown to be associated with cardiovascular disease. Nevertheless, the relationship between LAP and cognitive...

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Autores principales: Xie, Yanyou, Li, Junpei, Yu, Guotao, Zhou, Xinlei, Zhou, Wei, Zhu, Lingjuan, Wang, Tao, Huang, Xiao, Bao, Huihui, Cheng, Xiaoshu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851034/
https://www.ncbi.nlm.nih.gov/pubmed/35185745
http://dx.doi.org/10.3389/fneur.2021.732757
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author Xie, Yanyou
Li, Junpei
Yu, Guotao
Zhou, Xinlei
Zhou, Wei
Zhu, Lingjuan
Wang, Tao
Huang, Xiao
Bao, Huihui
Cheng, Xiaoshu
author_facet Xie, Yanyou
Li, Junpei
Yu, Guotao
Zhou, Xinlei
Zhou, Wei
Zhu, Lingjuan
Wang, Tao
Huang, Xiao
Bao, Huihui
Cheng, Xiaoshu
author_sort Xie, Yanyou
collection PubMed
description BACKGROUND: Hypertension is a major cardiovascular risk factor for cognitive impairment. Lipid accumulation product (LAP), an index that represents fat overaccumulation in the body, has been shown to be associated with cardiovascular disease. Nevertheless, the relationship between LAP and cognitive function in hypertensive patients with normal weight has been infrequently studied. OBJECTIVE: This study aimed to assess the relationship between LAP and cognitive function in hypertensive patients with normal weight. METHODS: This study included 5,542 Chinese hypertensive patients with normal weight. Cognitive function was evaluated using the Mini-Mental State Examination (MMSE). The relationship between LAP and MMSE scores was evaluated using multiple linear regression. RESULTS: The mean age of the participants was 64.8 ± 9.3 years, and 2,700 were men (48.7%). The mean MMSE score was 24.5 ± 5.1 in men and 19.2 ± 6.5 in women. The mean LAP was 26.2 ± 25.5 in men and 42.5 ± 34 in women. Log(10)-LAP showed a significant positive association with MMSE score (men: β = 0.69, 95% CI 0.14–1.24, p = 0.015; women: β = 1.03, 95% CI 0.16–1.90, p = 0.020). When LAP was divided into 3 groups according to tertiles, participants in the third LAP tertile had higher MMSE scores for both men (p for trend = 0.04) and women (p for trend = 0.015). CONCLUSION: LAP showed an independent positive association with MMSE in Chinese hypertensive patients with normal weight.
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spelling pubmed-88510342022-02-18 Association Between Lipid Accumulation Product and Cognitive Function in Hypertensive Patients With Normal Weight: Insight From the China H-type Hypertension Registry Study Xie, Yanyou Li, Junpei Yu, Guotao Zhou, Xinlei Zhou, Wei Zhu, Lingjuan Wang, Tao Huang, Xiao Bao, Huihui Cheng, Xiaoshu Front Neurol Neurology BACKGROUND: Hypertension is a major cardiovascular risk factor for cognitive impairment. Lipid accumulation product (LAP), an index that represents fat overaccumulation in the body, has been shown to be associated with cardiovascular disease. Nevertheless, the relationship between LAP and cognitive function in hypertensive patients with normal weight has been infrequently studied. OBJECTIVE: This study aimed to assess the relationship between LAP and cognitive function in hypertensive patients with normal weight. METHODS: This study included 5,542 Chinese hypertensive patients with normal weight. Cognitive function was evaluated using the Mini-Mental State Examination (MMSE). The relationship between LAP and MMSE scores was evaluated using multiple linear regression. RESULTS: The mean age of the participants was 64.8 ± 9.3 years, and 2,700 were men (48.7%). The mean MMSE score was 24.5 ± 5.1 in men and 19.2 ± 6.5 in women. The mean LAP was 26.2 ± 25.5 in men and 42.5 ± 34 in women. Log(10)-LAP showed a significant positive association with MMSE score (men: β = 0.69, 95% CI 0.14–1.24, p = 0.015; women: β = 1.03, 95% CI 0.16–1.90, p = 0.020). When LAP was divided into 3 groups according to tertiles, participants in the third LAP tertile had higher MMSE scores for both men (p for trend = 0.04) and women (p for trend = 0.015). CONCLUSION: LAP showed an independent positive association with MMSE in Chinese hypertensive patients with normal weight. Frontiers Media S.A. 2022-02-03 /pmc/articles/PMC8851034/ /pubmed/35185745 http://dx.doi.org/10.3389/fneur.2021.732757 Text en Copyright © 2022 Xie, Li, Yu, Zhou, Zhou, Zhu, Wang, Huang, Bao and Cheng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Xie, Yanyou
Li, Junpei
Yu, Guotao
Zhou, Xinlei
Zhou, Wei
Zhu, Lingjuan
Wang, Tao
Huang, Xiao
Bao, Huihui
Cheng, Xiaoshu
Association Between Lipid Accumulation Product and Cognitive Function in Hypertensive Patients With Normal Weight: Insight From the China H-type Hypertension Registry Study
title Association Between Lipid Accumulation Product and Cognitive Function in Hypertensive Patients With Normal Weight: Insight From the China H-type Hypertension Registry Study
title_full Association Between Lipid Accumulation Product and Cognitive Function in Hypertensive Patients With Normal Weight: Insight From the China H-type Hypertension Registry Study
title_fullStr Association Between Lipid Accumulation Product and Cognitive Function in Hypertensive Patients With Normal Weight: Insight From the China H-type Hypertension Registry Study
title_full_unstemmed Association Between Lipid Accumulation Product and Cognitive Function in Hypertensive Patients With Normal Weight: Insight From the China H-type Hypertension Registry Study
title_short Association Between Lipid Accumulation Product and Cognitive Function in Hypertensive Patients With Normal Weight: Insight From the China H-type Hypertension Registry Study
title_sort association between lipid accumulation product and cognitive function in hypertensive patients with normal weight: insight from the china h-type hypertension registry study
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851034/
https://www.ncbi.nlm.nih.gov/pubmed/35185745
http://dx.doi.org/10.3389/fneur.2021.732757
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