Expanding the TDP-43 Proteinopathy Pathway From Neurons to Muscle: Physiological and Pathophysiological Functions

TAR DNA-binding protein 43, mostly referred to as TDP-43 (encoded by the TARDBP gene) is strongly linked to the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). From the identification of TDP-43 positive aggregates in the brains and spinal cords of ALS/FTD patie...

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Detalles Bibliográficos
Autores principales: Versluys, Lauren, Ervilha Pereira, Pedro, Schuermans, Nika, De Paepe, Boel, De Bleecker, Jan L., Bogaert, Elke, Dermaut, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851062/
https://www.ncbi.nlm.nih.gov/pubmed/35185458
http://dx.doi.org/10.3389/fnins.2022.815765

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