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Exposure driven dose escalation design with overdose control: Concept and first real life experience in an oncology phase I trial
BACKGROUND: Escalation With Overdose Control (EWOC) designs are increasingly used to ensure dose-toxicity curve of investigational oncology drugs is efficiently characterized during dose escalation steps. We propose a novel EWOC-based method that integrates the longitudinal pharmacokinetic (PK) data...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851091/ https://www.ncbi.nlm.nih.gov/pubmed/35198796 http://dx.doi.org/10.1016/j.conctc.2022.100901 |