Inducible caspase-9 suicide gene under control of endogenous oct4 to safeguard mouse and human pluripotent stem cell therapy

Pluripotent stem cells (PSCs) are promising in regenerative medicine. A major challenge of PSC therapy is the risk of teratoma formation because of the contamination of undifferentiated stem cells. Constitutive promoters or endogenous SOX2 promoters have been used to drive inducible caspase-9 (iCasp...

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Detalles Bibliográficos
Autores principales: Liu, Yang, Yang, Yang, Suo, Yangyang, Li, Chuan, Chen, Min, Zheng, Shuwen, Li, Hao, Tang, Chengcheng, Fan, Nana, Lan, Ting, Zhou, Jizeng, Li, Yingying, Wang, Jiaowei, Chen, Huangyao, Zou, Qingjian, Lai, Liangxue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851157/
https://www.ncbi.nlm.nih.gov/pubmed/35229007
http://dx.doi.org/10.1016/j.omtm.2022.01.014

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