Pneumocystis Pneumonia in a Patient with Ovarian Cancer Receiving Olaparib Therapy

We herein report a case of pneumocystis pneumonia (PCP) in a 77-year-old woman with ovarian cancer who was receiving olaparib therapy. After the patient's second relapse of ovarian cancer, she was administered olaparib as maintenance therapy following successful completion of docetaxel and carb...

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Detalles Bibliográficos
Autores principales: Himeji, Daisuke, Tanaka, Gen-ichi, Shiiba, Ritsuya, Matsumoto, Ryoichi, Takamura, Kazuhiro, Morishita, Hirotaka, Taniguchi, Shuichi, Moriguchi, Sayaka, Marutsuka, Kousuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851181/
https://www.ncbi.nlm.nih.gov/pubmed/34248119
http://dx.doi.org/10.2169/internalmedicine.7485-21
Descripción
Sumario:We herein report a case of pneumocystis pneumonia (PCP) in a 77-year-old woman with ovarian cancer who was receiving olaparib therapy. After the patient's second relapse of ovarian cancer, she was administered olaparib as maintenance therapy following successful completion of docetaxel and carboplatin therapy. On receiving olaparib, she showed symptoms of a fever and malaise. Based on laboratory and imaging findings, she was diagnosed with PCP. After treatment with corticosteroids and trimethoprim/sulfamethoxazole followed by atovaquone, the patient's general condition improved. The lymphocytopenia observed after olaparib administration may have been associated with the development of PCP.

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