Pneumocystis Pneumonia in a Patient with Ovarian Cancer Receiving Olaparib Therapy

We herein report a case of pneumocystis pneumonia (PCP) in a 77-year-old woman with ovarian cancer who was receiving olaparib therapy. After the patient's second relapse of ovarian cancer, she was administered olaparib as maintenance therapy following successful completion of docetaxel and carb...

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Autores principales: Himeji, Daisuke, Tanaka, Gen-ichi, Shiiba, Ritsuya, Matsumoto, Ryoichi, Takamura, Kazuhiro, Morishita, Hirotaka, Taniguchi, Shuichi, Moriguchi, Sayaka, Marutsuka, Kousuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851181/
https://www.ncbi.nlm.nih.gov/pubmed/34248119
http://dx.doi.org/10.2169/internalmedicine.7485-21
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author Himeji, Daisuke
Tanaka, Gen-ichi
Shiiba, Ritsuya
Matsumoto, Ryoichi
Takamura, Kazuhiro
Morishita, Hirotaka
Taniguchi, Shuichi
Moriguchi, Sayaka
Marutsuka, Kousuke
author_facet Himeji, Daisuke
Tanaka, Gen-ichi
Shiiba, Ritsuya
Matsumoto, Ryoichi
Takamura, Kazuhiro
Morishita, Hirotaka
Taniguchi, Shuichi
Moriguchi, Sayaka
Marutsuka, Kousuke
author_sort Himeji, Daisuke
collection PubMed
description We herein report a case of pneumocystis pneumonia (PCP) in a 77-year-old woman with ovarian cancer who was receiving olaparib therapy. After the patient's second relapse of ovarian cancer, she was administered olaparib as maintenance therapy following successful completion of docetaxel and carboplatin therapy. On receiving olaparib, she showed symptoms of a fever and malaise. Based on laboratory and imaging findings, she was diagnosed with PCP. After treatment with corticosteroids and trimethoprim/sulfamethoxazole followed by atovaquone, the patient's general condition improved. The lymphocytopenia observed after olaparib administration may have been associated with the development of PCP.
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spelling pubmed-88511812022-03-09 Pneumocystis Pneumonia in a Patient with Ovarian Cancer Receiving Olaparib Therapy Himeji, Daisuke Tanaka, Gen-ichi Shiiba, Ritsuya Matsumoto, Ryoichi Takamura, Kazuhiro Morishita, Hirotaka Taniguchi, Shuichi Moriguchi, Sayaka Marutsuka, Kousuke Intern Med Case Report We herein report a case of pneumocystis pneumonia (PCP) in a 77-year-old woman with ovarian cancer who was receiving olaparib therapy. After the patient's second relapse of ovarian cancer, she was administered olaparib as maintenance therapy following successful completion of docetaxel and carboplatin therapy. On receiving olaparib, she showed symptoms of a fever and malaise. Based on laboratory and imaging findings, she was diagnosed with PCP. After treatment with corticosteroids and trimethoprim/sulfamethoxazole followed by atovaquone, the patient's general condition improved. The lymphocytopenia observed after olaparib administration may have been associated with the development of PCP. The Japanese Society of Internal Medicine 2021-07-10 2022-01-15 /pmc/articles/PMC8851181/ /pubmed/34248119 http://dx.doi.org/10.2169/internalmedicine.7485-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Himeji, Daisuke
Tanaka, Gen-ichi
Shiiba, Ritsuya
Matsumoto, Ryoichi
Takamura, Kazuhiro
Morishita, Hirotaka
Taniguchi, Shuichi
Moriguchi, Sayaka
Marutsuka, Kousuke
Pneumocystis Pneumonia in a Patient with Ovarian Cancer Receiving Olaparib Therapy
title Pneumocystis Pneumonia in a Patient with Ovarian Cancer Receiving Olaparib Therapy
title_full Pneumocystis Pneumonia in a Patient with Ovarian Cancer Receiving Olaparib Therapy
title_fullStr Pneumocystis Pneumonia in a Patient with Ovarian Cancer Receiving Olaparib Therapy
title_full_unstemmed Pneumocystis Pneumonia in a Patient with Ovarian Cancer Receiving Olaparib Therapy
title_short Pneumocystis Pneumonia in a Patient with Ovarian Cancer Receiving Olaparib Therapy
title_sort pneumocystis pneumonia in a patient with ovarian cancer receiving olaparib therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851181/
https://www.ncbi.nlm.nih.gov/pubmed/34248119
http://dx.doi.org/10.2169/internalmedicine.7485-21
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