Convulsive Seizure Due to Hypomagnesemia Caused by Short-term Vonoprazan Intake

A 71-year-old woman was admitted for the treatment of diffuse large B-cell lymphoma of the ileum. She had been taking lansoprazole but was switched to vonoprazan due to epigastric discomfort. Three weeks after starting vonoprazan intake, she had a convulsive seizure, and a blood test showed hypomagn...

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Autores principales: Aiba, Masayuki, Tsutsumi, Yutaka, Nagai, Jun, Tateno, Takahiro, Ito, Shinichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851186/
https://www.ncbi.nlm.nih.gov/pubmed/34275986
http://dx.doi.org/10.2169/internalmedicine.7758-21
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author Aiba, Masayuki
Tsutsumi, Yutaka
Nagai, Jun
Tateno, Takahiro
Ito, Shinichi
author_facet Aiba, Masayuki
Tsutsumi, Yutaka
Nagai, Jun
Tateno, Takahiro
Ito, Shinichi
author_sort Aiba, Masayuki
collection PubMed
description A 71-year-old woman was admitted for the treatment of diffuse large B-cell lymphoma of the ileum. She had been taking lansoprazole but was switched to vonoprazan due to epigastric discomfort. Three weeks after starting vonoprazan intake, she had a convulsive seizure, and a blood test showed hypomagnesiemia. The cause of hypomagnesemia was considered to be malabsorption of magnesium from the intestinal tract associated with vonoprazan. After discontinuation of vonoprazan, the magnesium level quickly recovered, and the seizures did not relapse. It is important to consider the risk of hypomagnesemia in patients taking vonoprazan, even for a short period of time.
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spelling pubmed-88511862022-03-09 Convulsive Seizure Due to Hypomagnesemia Caused by Short-term Vonoprazan Intake Aiba, Masayuki Tsutsumi, Yutaka Nagai, Jun Tateno, Takahiro Ito, Shinichi Intern Med Case Report A 71-year-old woman was admitted for the treatment of diffuse large B-cell lymphoma of the ileum. She had been taking lansoprazole but was switched to vonoprazan due to epigastric discomfort. Three weeks after starting vonoprazan intake, she had a convulsive seizure, and a blood test showed hypomagnesiemia. The cause of hypomagnesemia was considered to be malabsorption of magnesium from the intestinal tract associated with vonoprazan. After discontinuation of vonoprazan, the magnesium level quickly recovered, and the seizures did not relapse. It is important to consider the risk of hypomagnesemia in patients taking vonoprazan, even for a short period of time. The Japanese Society of Internal Medicine 2021-07-17 2022-01-15 /pmc/articles/PMC8851186/ /pubmed/34275986 http://dx.doi.org/10.2169/internalmedicine.7758-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Aiba, Masayuki
Tsutsumi, Yutaka
Nagai, Jun
Tateno, Takahiro
Ito, Shinichi
Convulsive Seizure Due to Hypomagnesemia Caused by Short-term Vonoprazan Intake
title Convulsive Seizure Due to Hypomagnesemia Caused by Short-term Vonoprazan Intake
title_full Convulsive Seizure Due to Hypomagnesemia Caused by Short-term Vonoprazan Intake
title_fullStr Convulsive Seizure Due to Hypomagnesemia Caused by Short-term Vonoprazan Intake
title_full_unstemmed Convulsive Seizure Due to Hypomagnesemia Caused by Short-term Vonoprazan Intake
title_short Convulsive Seizure Due to Hypomagnesemia Caused by Short-term Vonoprazan Intake
title_sort convulsive seizure due to hypomagnesemia caused by short-term vonoprazan intake
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851186/
https://www.ncbi.nlm.nih.gov/pubmed/34275986
http://dx.doi.org/10.2169/internalmedicine.7758-21
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