Modes of Brain Cell Death Following Intracerebral Hemorrhage

Intracerebral hemorrhage (ICH) is a devastating form of stroke with high rates of mortality and morbidity. It induces cell death that is responsible for neurological deficits postinjury. There are no therapies that effectively mitigate cell death to treat ICH. This review aims to summarize our knowl...

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Autores principales: Zhang, Yan, Khan, Suliman, Liu, Yang, Zhang, Ruiyi, Li, Hongmin, Wu, Guofeng, Tang, Zhouping, Xue, Mengzhou, Yong, V. Wee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851202/
https://www.ncbi.nlm.nih.gov/pubmed/35185473
http://dx.doi.org/10.3389/fncel.2022.799753
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author Zhang, Yan
Khan, Suliman
Liu, Yang
Zhang, Ruiyi
Li, Hongmin
Wu, Guofeng
Tang, Zhouping
Xue, Mengzhou
Yong, V. Wee
author_facet Zhang, Yan
Khan, Suliman
Liu, Yang
Zhang, Ruiyi
Li, Hongmin
Wu, Guofeng
Tang, Zhouping
Xue, Mengzhou
Yong, V. Wee
author_sort Zhang, Yan
collection PubMed
description Intracerebral hemorrhage (ICH) is a devastating form of stroke with high rates of mortality and morbidity. It induces cell death that is responsible for neurological deficits postinjury. There are no therapies that effectively mitigate cell death to treat ICH. This review aims to summarize our knowledge of ICH-induced cell death with a focus on apoptosis and necrosis. We also discuss the involvement of ICH in recently described modes of cell death including necroptosis, pyroptosis, ferroptosis, autophagy, and parthanatos. We summarize treatment strategies to mitigate brain injury based on particular cell death pathways after ICH.
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spelling pubmed-88512022022-02-18 Modes of Brain Cell Death Following Intracerebral Hemorrhage Zhang, Yan Khan, Suliman Liu, Yang Zhang, Ruiyi Li, Hongmin Wu, Guofeng Tang, Zhouping Xue, Mengzhou Yong, V. Wee Front Cell Neurosci Neuroscience Intracerebral hemorrhage (ICH) is a devastating form of stroke with high rates of mortality and morbidity. It induces cell death that is responsible for neurological deficits postinjury. There are no therapies that effectively mitigate cell death to treat ICH. This review aims to summarize our knowledge of ICH-induced cell death with a focus on apoptosis and necrosis. We also discuss the involvement of ICH in recently described modes of cell death including necroptosis, pyroptosis, ferroptosis, autophagy, and parthanatos. We summarize treatment strategies to mitigate brain injury based on particular cell death pathways after ICH. Frontiers Media S.A. 2022-02-03 /pmc/articles/PMC8851202/ /pubmed/35185473 http://dx.doi.org/10.3389/fncel.2022.799753 Text en Copyright © 2022 Zhang, Khan, Liu, Zhang, Li, Wu, Tang, Xue and Yong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zhang, Yan
Khan, Suliman
Liu, Yang
Zhang, Ruiyi
Li, Hongmin
Wu, Guofeng
Tang, Zhouping
Xue, Mengzhou
Yong, V. Wee
Modes of Brain Cell Death Following Intracerebral Hemorrhage
title Modes of Brain Cell Death Following Intracerebral Hemorrhage
title_full Modes of Brain Cell Death Following Intracerebral Hemorrhage
title_fullStr Modes of Brain Cell Death Following Intracerebral Hemorrhage
title_full_unstemmed Modes of Brain Cell Death Following Intracerebral Hemorrhage
title_short Modes of Brain Cell Death Following Intracerebral Hemorrhage
title_sort modes of brain cell death following intracerebral hemorrhage
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851202/
https://www.ncbi.nlm.nih.gov/pubmed/35185473
http://dx.doi.org/10.3389/fncel.2022.799753
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