Cargando…
Effects of dietary supplementation with itaconic acid on the growth performance, nutrient digestibility, slaughter variables, blood biochemical parameters, and intestinal morphology of broiler chickens
Itaconic acid (IA) is a biologically based unsaturated dicarboxylic acid secreted by mammalian cells. While IA has potential for use in multiple applications, information regarding the influence of IA on animal production remains scarce. This study investigated the effects of dietary IA supplementat...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851234/ https://www.ncbi.nlm.nih.gov/pubmed/35176702 http://dx.doi.org/10.1016/j.psj.2022.101732 |
_version_ | 1784652779020615680 |
---|---|
author | Zhu, Xin Zhang, Yinhang Zhao, Yingzhuo Tao, Lijuan Liu, Haiying Dong, Weiguo Yang, Guiqin Li, Lin |
author_facet | Zhu, Xin Zhang, Yinhang Zhao, Yingzhuo Tao, Lijuan Liu, Haiying Dong, Weiguo Yang, Guiqin Li, Lin |
author_sort | Zhu, Xin |
collection | PubMed |
description | Itaconic acid (IA) is a biologically based unsaturated dicarboxylic acid secreted by mammalian cells. While IA has potential for use in multiple applications, information regarding the influence of IA on animal production remains scarce. This study investigated the effects of dietary IA supplementation on the growth performance, nutrient digestibility, slaughter variables, blood parameters, and intestinal morphology of broiler chickens. A total of 360 one-day-old Arbor Acre broiler chicks were allotted to 6 groups, with 10 chicks per cage and 6 replicates per group in a randomized complete block design. Broiler chicks were fed a basal diet with 0 (control), 0.2, 0.4, 0.6, 0.8, or 1.0% IA. The experimental period lasted from 1 to 42 d of age. Dietary IA supplementation did not affect average daily gain (ADG) and feed/gain ratio (F/G) but quadratically increased average daily feed intake (ADFI) and linearly increased crude protein (CP) digestibility during the grower period (d 22–42). A higher breast and thigh muscle yield and a lower abdominal fat yield were observed in a linear and quadratic manner with the IA supplementation. Adding IA to the diet had significant effects on superoxide dismutase (SOD), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and catalase (CAT) levels in serum at d 21 and on total antioxidation capacity (T-AOC) at d 42. There were linear and quadratic increases in villus height and the villus height/crypt depth ratio (V/C) of the duodenum and villus height of the jejunum with the supplementation of IA. Regression analyses for ADFI, dressed yield, breast and thigh muscle yield, abdominal fat yield, serum ALT, CAT, and SOD levels, villus length of the duodenum and jejunum, and V/C of the duodenum indicated that the optimal dietary IA supplementation would be from 0.4 to 0.7%. From an economic perspective, a level of 0.4% IA in the broiler diet is recommended for improving the nutrient digestibility, slaughter performance, antioxidant ability, and intestinal morphology of broiler chickens. |
format | Online Article Text |
id | pubmed-8851234 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-88512342022-02-22 Effects of dietary supplementation with itaconic acid on the growth performance, nutrient digestibility, slaughter variables, blood biochemical parameters, and intestinal morphology of broiler chickens Zhu, Xin Zhang, Yinhang Zhao, Yingzhuo Tao, Lijuan Liu, Haiying Dong, Weiguo Yang, Guiqin Li, Lin Poult Sci Metabolism and Nutrition Itaconic acid (IA) is a biologically based unsaturated dicarboxylic acid secreted by mammalian cells. While IA has potential for use in multiple applications, information regarding the influence of IA on animal production remains scarce. This study investigated the effects of dietary IA supplementation on the growth performance, nutrient digestibility, slaughter variables, blood parameters, and intestinal morphology of broiler chickens. A total of 360 one-day-old Arbor Acre broiler chicks were allotted to 6 groups, with 10 chicks per cage and 6 replicates per group in a randomized complete block design. Broiler chicks were fed a basal diet with 0 (control), 0.2, 0.4, 0.6, 0.8, or 1.0% IA. The experimental period lasted from 1 to 42 d of age. Dietary IA supplementation did not affect average daily gain (ADG) and feed/gain ratio (F/G) but quadratically increased average daily feed intake (ADFI) and linearly increased crude protein (CP) digestibility during the grower period (d 22–42). A higher breast and thigh muscle yield and a lower abdominal fat yield were observed in a linear and quadratic manner with the IA supplementation. Adding IA to the diet had significant effects on superoxide dismutase (SOD), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and catalase (CAT) levels in serum at d 21 and on total antioxidation capacity (T-AOC) at d 42. There were linear and quadratic increases in villus height and the villus height/crypt depth ratio (V/C) of the duodenum and villus height of the jejunum with the supplementation of IA. Regression analyses for ADFI, dressed yield, breast and thigh muscle yield, abdominal fat yield, serum ALT, CAT, and SOD levels, villus length of the duodenum and jejunum, and V/C of the duodenum indicated that the optimal dietary IA supplementation would be from 0.4 to 0.7%. From an economic perspective, a level of 0.4% IA in the broiler diet is recommended for improving the nutrient digestibility, slaughter performance, antioxidant ability, and intestinal morphology of broiler chickens. Elsevier 2022-01-15 /pmc/articles/PMC8851234/ /pubmed/35176702 http://dx.doi.org/10.1016/j.psj.2022.101732 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Metabolism and Nutrition Zhu, Xin Zhang, Yinhang Zhao, Yingzhuo Tao, Lijuan Liu, Haiying Dong, Weiguo Yang, Guiqin Li, Lin Effects of dietary supplementation with itaconic acid on the growth performance, nutrient digestibility, slaughter variables, blood biochemical parameters, and intestinal morphology of broiler chickens |
title | Effects of dietary supplementation with itaconic acid on the growth performance, nutrient digestibility, slaughter variables, blood biochemical parameters, and intestinal morphology of broiler chickens |
title_full | Effects of dietary supplementation with itaconic acid on the growth performance, nutrient digestibility, slaughter variables, blood biochemical parameters, and intestinal morphology of broiler chickens |
title_fullStr | Effects of dietary supplementation with itaconic acid on the growth performance, nutrient digestibility, slaughter variables, blood biochemical parameters, and intestinal morphology of broiler chickens |
title_full_unstemmed | Effects of dietary supplementation with itaconic acid on the growth performance, nutrient digestibility, slaughter variables, blood biochemical parameters, and intestinal morphology of broiler chickens |
title_short | Effects of dietary supplementation with itaconic acid on the growth performance, nutrient digestibility, slaughter variables, blood biochemical parameters, and intestinal morphology of broiler chickens |
title_sort | effects of dietary supplementation with itaconic acid on the growth performance, nutrient digestibility, slaughter variables, blood biochemical parameters, and intestinal morphology of broiler chickens |
topic | Metabolism and Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851234/ https://www.ncbi.nlm.nih.gov/pubmed/35176702 http://dx.doi.org/10.1016/j.psj.2022.101732 |
work_keys_str_mv | AT zhuxin effectsofdietarysupplementationwithitaconicacidonthegrowthperformancenutrientdigestibilityslaughtervariablesbloodbiochemicalparametersandintestinalmorphologyofbroilerchickens AT zhangyinhang effectsofdietarysupplementationwithitaconicacidonthegrowthperformancenutrientdigestibilityslaughtervariablesbloodbiochemicalparametersandintestinalmorphologyofbroilerchickens AT zhaoyingzhuo effectsofdietarysupplementationwithitaconicacidonthegrowthperformancenutrientdigestibilityslaughtervariablesbloodbiochemicalparametersandintestinalmorphologyofbroilerchickens AT taolijuan effectsofdietarysupplementationwithitaconicacidonthegrowthperformancenutrientdigestibilityslaughtervariablesbloodbiochemicalparametersandintestinalmorphologyofbroilerchickens AT liuhaiying effectsofdietarysupplementationwithitaconicacidonthegrowthperformancenutrientdigestibilityslaughtervariablesbloodbiochemicalparametersandintestinalmorphologyofbroilerchickens AT dongweiguo effectsofdietarysupplementationwithitaconicacidonthegrowthperformancenutrientdigestibilityslaughtervariablesbloodbiochemicalparametersandintestinalmorphologyofbroilerchickens AT yangguiqin effectsofdietarysupplementationwithitaconicacidonthegrowthperformancenutrientdigestibilityslaughtervariablesbloodbiochemicalparametersandintestinalmorphologyofbroilerchickens AT lilin effectsofdietarysupplementationwithitaconicacidonthegrowthperformancenutrientdigestibilityslaughtervariablesbloodbiochemicalparametersandintestinalmorphologyofbroilerchickens |