Potential Biomarkers for Liver Cancer Diagnosis Based on Multi-Omics Strategy

Liver cancer is the fourth leading cause of cancer-related death worldwide. Hepatocellular carcinoma (HCC) accounts for about 85%-90% of all primary liver malignancies. However, only 20-30% of HCC patients are eligible for curative therapy mainly due to the lack of early-detection strategies, highli...

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Autores principales: Chen, Fanghua, Wang, Junming, Wu, Yingcheng, Gao, Qiang, Zhang, Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851237/
https://www.ncbi.nlm.nih.gov/pubmed/35186756
http://dx.doi.org/10.3389/fonc.2022.822449
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author Chen, Fanghua
Wang, Junming
Wu, Yingcheng
Gao, Qiang
Zhang, Shu
author_facet Chen, Fanghua
Wang, Junming
Wu, Yingcheng
Gao, Qiang
Zhang, Shu
author_sort Chen, Fanghua
collection PubMed
description Liver cancer is the fourth leading cause of cancer-related death worldwide. Hepatocellular carcinoma (HCC) accounts for about 85%-90% of all primary liver malignancies. However, only 20-30% of HCC patients are eligible for curative therapy mainly due to the lack of early-detection strategies, highlighting the significance of reliable and accurate biomarkers. The integration of multi-omics became an important tool for biomarker screening and unique alterations in tumor-associated genes, transcripts, proteins, post-translational modifications and metabolites have been observed. We here summarized the novel biomarkers for HCC diagnosis based on multi-omics technology as well as the clinical significance of these potential biomarkers in the early detection of HCC.
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spelling pubmed-88512372022-02-18 Potential Biomarkers for Liver Cancer Diagnosis Based on Multi-Omics Strategy Chen, Fanghua Wang, Junming Wu, Yingcheng Gao, Qiang Zhang, Shu Front Oncol Oncology Liver cancer is the fourth leading cause of cancer-related death worldwide. Hepatocellular carcinoma (HCC) accounts for about 85%-90% of all primary liver malignancies. However, only 20-30% of HCC patients are eligible for curative therapy mainly due to the lack of early-detection strategies, highlighting the significance of reliable and accurate biomarkers. The integration of multi-omics became an important tool for biomarker screening and unique alterations in tumor-associated genes, transcripts, proteins, post-translational modifications and metabolites have been observed. We here summarized the novel biomarkers for HCC diagnosis based on multi-omics technology as well as the clinical significance of these potential biomarkers in the early detection of HCC. Frontiers Media S.A. 2022-02-03 /pmc/articles/PMC8851237/ /pubmed/35186756 http://dx.doi.org/10.3389/fonc.2022.822449 Text en Copyright © 2022 Chen, Wang, Wu, Gao and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Chen, Fanghua
Wang, Junming
Wu, Yingcheng
Gao, Qiang
Zhang, Shu
Potential Biomarkers for Liver Cancer Diagnosis Based on Multi-Omics Strategy
title Potential Biomarkers for Liver Cancer Diagnosis Based on Multi-Omics Strategy
title_full Potential Biomarkers for Liver Cancer Diagnosis Based on Multi-Omics Strategy
title_fullStr Potential Biomarkers for Liver Cancer Diagnosis Based on Multi-Omics Strategy
title_full_unstemmed Potential Biomarkers for Liver Cancer Diagnosis Based on Multi-Omics Strategy
title_short Potential Biomarkers for Liver Cancer Diagnosis Based on Multi-Omics Strategy
title_sort potential biomarkers for liver cancer diagnosis based on multi-omics strategy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851237/
https://www.ncbi.nlm.nih.gov/pubmed/35186756
http://dx.doi.org/10.3389/fonc.2022.822449
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AT gaoqiang potentialbiomarkersforlivercancerdiagnosisbasedonmultiomicsstrategy
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