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The effect of progesteron for expression delta (δ) opioid receptor spinal cord through peripheral nerve injury

BACKGROUND: Neuropathic pain is a major problem to date because of its high prevalence and lack of effective treatment. Neuropathic pain processes can be influenced by many factors and at various levels of the nervous system, including progesterone and the opioid system. The various mechanisms of th...

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Autores principales: Priyanto, Bambang, Rosyidi, Rohadi Muhammad, Islam, Andi Asadul, Turchan, Agus, Pintaningrum, Yusra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851263/
https://www.ncbi.nlm.nih.gov/pubmed/35198196
http://dx.doi.org/10.1016/j.amsu.2022.103376
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author Priyanto, Bambang
Rosyidi, Rohadi Muhammad
Islam, Andi Asadul
Turchan, Agus
Pintaningrum, Yusra
author_facet Priyanto, Bambang
Rosyidi, Rohadi Muhammad
Islam, Andi Asadul
Turchan, Agus
Pintaningrum, Yusra
author_sort Priyanto, Bambang
collection PubMed
description BACKGROUND: Neuropathic pain is a major problem to date because of its high prevalence and lack of effective treatment. Neuropathic pain processes can be influenced by many factors and at various levels of the nervous system, including progesterone and the opioid system. The various mechanisms of the effect of progesterone on pain are still controversial, while the effect of progesterone on the activation of the opioid system also needs to be proven. This study aimed to determine the effect of progesterone on pain through the modulation mechanism of the opioid system. METHODS: This research is a completely randomized experimental study using male wistar rats aged around three months at the Experimental Animal Laboratory, Department of Medical Biochemistry, Faculty of Medicine, Airlangga University. RESULTS: The result was analyzed by using statistical analysis of two independent samples (t-test). The t value was obtained at 6.880, p = 0.000 (p < 0.05). CONCLUSION: It was shown that there was a significant difference in the delta (δ) opioid receptor expression between the control group and the progesterone group, which indicated that progesterone causes an increase in the delta (δ) opioid receptor expression in the spinal cord.
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spelling pubmed-88512632022-02-22 The effect of progesteron for expression delta (δ) opioid receptor spinal cord through peripheral nerve injury Priyanto, Bambang Rosyidi, Rohadi Muhammad Islam, Andi Asadul Turchan, Agus Pintaningrum, Yusra Ann Med Surg (Lond) Experimental Research BACKGROUND: Neuropathic pain is a major problem to date because of its high prevalence and lack of effective treatment. Neuropathic pain processes can be influenced by many factors and at various levels of the nervous system, including progesterone and the opioid system. The various mechanisms of the effect of progesterone on pain are still controversial, while the effect of progesterone on the activation of the opioid system also needs to be proven. This study aimed to determine the effect of progesterone on pain through the modulation mechanism of the opioid system. METHODS: This research is a completely randomized experimental study using male wistar rats aged around three months at the Experimental Animal Laboratory, Department of Medical Biochemistry, Faculty of Medicine, Airlangga University. RESULTS: The result was analyzed by using statistical analysis of two independent samples (t-test). The t value was obtained at 6.880, p = 0.000 (p < 0.05). CONCLUSION: It was shown that there was a significant difference in the delta (δ) opioid receptor expression between the control group and the progesterone group, which indicated that progesterone causes an increase in the delta (δ) opioid receptor expression in the spinal cord. Elsevier 2022-02-11 /pmc/articles/PMC8851263/ /pubmed/35198196 http://dx.doi.org/10.1016/j.amsu.2022.103376 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Experimental Research
Priyanto, Bambang
Rosyidi, Rohadi Muhammad
Islam, Andi Asadul
Turchan, Agus
Pintaningrum, Yusra
The effect of progesteron for expression delta (δ) opioid receptor spinal cord through peripheral nerve injury
title The effect of progesteron for expression delta (δ) opioid receptor spinal cord through peripheral nerve injury
title_full The effect of progesteron for expression delta (δ) opioid receptor spinal cord through peripheral nerve injury
title_fullStr The effect of progesteron for expression delta (δ) opioid receptor spinal cord through peripheral nerve injury
title_full_unstemmed The effect of progesteron for expression delta (δ) opioid receptor spinal cord through peripheral nerve injury
title_short The effect of progesteron for expression delta (δ) opioid receptor spinal cord through peripheral nerve injury
title_sort effect of progesteron for expression delta (δ) opioid receptor spinal cord through peripheral nerve injury
topic Experimental Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851263/
https://www.ncbi.nlm.nih.gov/pubmed/35198196
http://dx.doi.org/10.1016/j.amsu.2022.103376
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