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The effect of progesteron for expression delta (δ) opioid receptor spinal cord through peripheral nerve injury
BACKGROUND: Neuropathic pain is a major problem to date because of its high prevalence and lack of effective treatment. Neuropathic pain processes can be influenced by many factors and at various levels of the nervous system, including progesterone and the opioid system. The various mechanisms of th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851263/ https://www.ncbi.nlm.nih.gov/pubmed/35198196 http://dx.doi.org/10.1016/j.amsu.2022.103376 |
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author | Priyanto, Bambang Rosyidi, Rohadi Muhammad Islam, Andi Asadul Turchan, Agus Pintaningrum, Yusra |
author_facet | Priyanto, Bambang Rosyidi, Rohadi Muhammad Islam, Andi Asadul Turchan, Agus Pintaningrum, Yusra |
author_sort | Priyanto, Bambang |
collection | PubMed |
description | BACKGROUND: Neuropathic pain is a major problem to date because of its high prevalence and lack of effective treatment. Neuropathic pain processes can be influenced by many factors and at various levels of the nervous system, including progesterone and the opioid system. The various mechanisms of the effect of progesterone on pain are still controversial, while the effect of progesterone on the activation of the opioid system also needs to be proven. This study aimed to determine the effect of progesterone on pain through the modulation mechanism of the opioid system. METHODS: This research is a completely randomized experimental study using male wistar rats aged around three months at the Experimental Animal Laboratory, Department of Medical Biochemistry, Faculty of Medicine, Airlangga University. RESULTS: The result was analyzed by using statistical analysis of two independent samples (t-test). The t value was obtained at 6.880, p = 0.000 (p < 0.05). CONCLUSION: It was shown that there was a significant difference in the delta (δ) opioid receptor expression between the control group and the progesterone group, which indicated that progesterone causes an increase in the delta (δ) opioid receptor expression in the spinal cord. |
format | Online Article Text |
id | pubmed-8851263 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-88512632022-02-22 The effect of progesteron for expression delta (δ) opioid receptor spinal cord through peripheral nerve injury Priyanto, Bambang Rosyidi, Rohadi Muhammad Islam, Andi Asadul Turchan, Agus Pintaningrum, Yusra Ann Med Surg (Lond) Experimental Research BACKGROUND: Neuropathic pain is a major problem to date because of its high prevalence and lack of effective treatment. Neuropathic pain processes can be influenced by many factors and at various levels of the nervous system, including progesterone and the opioid system. The various mechanisms of the effect of progesterone on pain are still controversial, while the effect of progesterone on the activation of the opioid system also needs to be proven. This study aimed to determine the effect of progesterone on pain through the modulation mechanism of the opioid system. METHODS: This research is a completely randomized experimental study using male wistar rats aged around three months at the Experimental Animal Laboratory, Department of Medical Biochemistry, Faculty of Medicine, Airlangga University. RESULTS: The result was analyzed by using statistical analysis of two independent samples (t-test). The t value was obtained at 6.880, p = 0.000 (p < 0.05). CONCLUSION: It was shown that there was a significant difference in the delta (δ) opioid receptor expression between the control group and the progesterone group, which indicated that progesterone causes an increase in the delta (δ) opioid receptor expression in the spinal cord. Elsevier 2022-02-11 /pmc/articles/PMC8851263/ /pubmed/35198196 http://dx.doi.org/10.1016/j.amsu.2022.103376 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Experimental Research Priyanto, Bambang Rosyidi, Rohadi Muhammad Islam, Andi Asadul Turchan, Agus Pintaningrum, Yusra The effect of progesteron for expression delta (δ) opioid receptor spinal cord through peripheral nerve injury |
title | The effect of progesteron for expression delta (δ) opioid receptor spinal cord through peripheral nerve injury |
title_full | The effect of progesteron for expression delta (δ) opioid receptor spinal cord through peripheral nerve injury |
title_fullStr | The effect of progesteron for expression delta (δ) opioid receptor spinal cord through peripheral nerve injury |
title_full_unstemmed | The effect of progesteron for expression delta (δ) opioid receptor spinal cord through peripheral nerve injury |
title_short | The effect of progesteron for expression delta (δ) opioid receptor spinal cord through peripheral nerve injury |
title_sort | effect of progesteron for expression delta (δ) opioid receptor spinal cord through peripheral nerve injury |
topic | Experimental Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851263/ https://www.ncbi.nlm.nih.gov/pubmed/35198196 http://dx.doi.org/10.1016/j.amsu.2022.103376 |
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