Mitochondrial-Derived Peptides in Diabetes and Its Complications

The changes of mitochondrial function are closely related to diabetes and its complications. Here we describe the effects of mitochondrial-derived peptides (MDPs), short peptides formed by transcription and translation of the open reading frame site in human mitochondrial DNA (mtDNA), on diabetes an...

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Autores principales: Wu, Ying, Sun, Liankun, Zhuang, Zhoudao, Hu, Xiaoqing, Dong, Delu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851315/
https://www.ncbi.nlm.nih.gov/pubmed/35185787
http://dx.doi.org/10.3389/fendo.2021.808120
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author Wu, Ying
Sun, Liankun
Zhuang, Zhoudao
Hu, Xiaoqing
Dong, Delu
author_facet Wu, Ying
Sun, Liankun
Zhuang, Zhoudao
Hu, Xiaoqing
Dong, Delu
author_sort Wu, Ying
collection PubMed
description The changes of mitochondrial function are closely related to diabetes and its complications. Here we describe the effects of mitochondrial-derived peptides (MDPs), short peptides formed by transcription and translation of the open reading frame site in human mitochondrial DNA (mtDNA), on diabetes and its complications. We mainly focus on MDPs that have been discovered so far, such as Humanin (HN), mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) and Small humanin-like peptides (SHLP 1-6), and elucidated the role of MDPs in diabetes and its major complications stroke and myocardial infarction by improving insulin resistance, inhibiting inflammatory response and anti-apoptosis. It provides more possibilities for the clinical application of mitochondrial derived peptides.
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spelling pubmed-88513152022-02-18 Mitochondrial-Derived Peptides in Diabetes and Its Complications Wu, Ying Sun, Liankun Zhuang, Zhoudao Hu, Xiaoqing Dong, Delu Front Endocrinol (Lausanne) Endocrinology The changes of mitochondrial function are closely related to diabetes and its complications. Here we describe the effects of mitochondrial-derived peptides (MDPs), short peptides formed by transcription and translation of the open reading frame site in human mitochondrial DNA (mtDNA), on diabetes and its complications. We mainly focus on MDPs that have been discovered so far, such as Humanin (HN), mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) and Small humanin-like peptides (SHLP 1-6), and elucidated the role of MDPs in diabetes and its major complications stroke and myocardial infarction by improving insulin resistance, inhibiting inflammatory response and anti-apoptosis. It provides more possibilities for the clinical application of mitochondrial derived peptides. Frontiers Media S.A. 2022-02-03 /pmc/articles/PMC8851315/ /pubmed/35185787 http://dx.doi.org/10.3389/fendo.2021.808120 Text en Copyright © 2022 Wu, Sun, Zhuang, Hu and Dong https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Wu, Ying
Sun, Liankun
Zhuang, Zhoudao
Hu, Xiaoqing
Dong, Delu
Mitochondrial-Derived Peptides in Diabetes and Its Complications
title Mitochondrial-Derived Peptides in Diabetes and Its Complications
title_full Mitochondrial-Derived Peptides in Diabetes and Its Complications
title_fullStr Mitochondrial-Derived Peptides in Diabetes and Its Complications
title_full_unstemmed Mitochondrial-Derived Peptides in Diabetes and Its Complications
title_short Mitochondrial-Derived Peptides in Diabetes and Its Complications
title_sort mitochondrial-derived peptides in diabetes and its complications
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851315/
https://www.ncbi.nlm.nih.gov/pubmed/35185787
http://dx.doi.org/10.3389/fendo.2021.808120
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AT dongdelu mitochondrialderivedpeptidesindiabetesanditscomplications

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